| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Fahmi Muhamad (日) (読)
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| 2. | (英) Yasui Gen (日) (読)
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| 3. | (英) Seki Kaito (日) (読)
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| 4. | 片山 将一 ([徳島大学.大学院医歯薬学研究部.薬学域.先端薬学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品病態生化学])
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| 5. | (英) Kaneko-Kawano Takako (日) (読)
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| 6. | (英) Inazu Tetsuya (日) (読)
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| 7. | (英) Kubota Yukihiko (日) (読)
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| 8. | (英) Ito Masahiro (日) (読)
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| ○題名 (必須): | □ | (英) In Silico Study of Rett Syndrome Treatment-Related Genes, MECP2, CDKL5, and FOXG1, by Evolutionary Classification and Disordered Region Assessment (日)
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| ○要約 (任意): | □ | (英) ) correspond to distinct neurodevelopmental disorders, given that a series of studies have indicated that RTT is also caused by alterations in either one of these genes. We investigated the evolution and molecular features of MeCP2, CDKL5, and FOXG1 and their binding partners using phylogenetic profiling to gain a better understanding of their similarities. We also predicted the structural order-disorder propensity and assessed the evolutionary rates per site of MeCP2, CDKL5, and FOXG1 to investigate the relationships between disordered structure and other related properties with RTT. Here, we provide insight to the structural characteristics, evolution and interaction landscapes of those three proteins. We also uncovered the disordered structure properties and evolution of those proteins which may provide valuable information for the development of therapeutic strategies of RTT. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Chordata (日) (読)
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| 3. | (英) Computer Simulation (日) (読)
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| 4. | 分子進化 (molecular evolution)
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| 5. | (英) Forkhead Transcription Factors (日) (読)
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| 6. | (英) Gene Ontology (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Methyl-CpG-Binding Protein 2 (日) (読)
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| 9. | (英) Mutation, Missense (日) (読)
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| 10. | (英) Nerve Tissue Proteins (日) (読)
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| 11. | (英) Organ Specificity (日) (読)
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| 12. | (英) Phylogeny (日) (読)
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| 13. | (英) Protein Binding (日) (読)
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| 14. | (英) Protein Processing, Post-Translational (日) (読)
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| 15. | (英) Protein-Serine-Threonine Kinases (日) (読)
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| 16. | (英) Rett Syndrome (日) (読)
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| 17. | (英) Subcellular Fractions (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Molecular Sciences (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
| ○ISSN (任意): | □ | 1422-0067
ISSN: 1661-6596
(pISSN: 1661-6596, eISSN: 1422-0067) Title: International journal of molecular sciencesTitle(ISO): Int J Mol SciPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 20
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| ○号 (必須): | □ | 22
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| ○頁 (必須): |
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| ○年月日 (必須): | □ | 西暦 2019年 11月 8日 (令和 元年 11月 8日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/ijms20225593 (→Scopusで検索)
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| ○PMID (任意): | □ | 31717404 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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