| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Morii Atsushi (日) (読)
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| 2. | 片山 将一 ([徳島大学.大学院医歯薬学研究部.薬学域.先端薬学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品病態生化学])
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| 3. | (英) Inazu Tetsuya (日) (読)
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| ○題名 (必須): | □ | (英) Establishment of a Simple Method for Inducing Neuronal Differentiation of P19 EC Cells without Embryoid Body Formation and Analysis of the Role of Histone Deacetylase 8 Activity in This Differentiation. (日)
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| ○要約 (任意): | □ | (英) 227 medium further enhanced differentiation. Furthermore, cells differentiated by the conventional method, as well as the new method, showed identical expression of the mature neuronal marker, neuronal nuclei. To determine whether our approach could be applied for neuronal studies, we measured histone deacetylase 8 (HDAC8) activity using an HDAC8 inhibitor and HDAC8-knockout P19 EC cells. Inhibition of HDAC8 activity suppressed neuronal maturation. Additionally, HDAC8-knockout cell lines showed immature differentiation compared to the wild-type cell line. These results indicate that HDAC8 directly regulates the neuronal differentiation of P19 EC cells. Thus, our method involving P19 EC cells can be used as an experimental system to study the nervous system. Moreover, this method is suitable for screening drugs that affect the nervous system and cell differentiation. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Line, Tumor (日) (読)
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| 3. | (英) Embryoid Bodies (日) (読)
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| 4. | (英) Histone Deacetylase Inhibitors (日) (読)
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| 5. | (英) Histone Deacetylases (日) (読)
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| 6. | (英) Hydroxamic Acids (日) (読)
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| 7. | (英) Mice, Inbred C3H (日) (読)
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| 8. | (英) Neurogenesis (日) (読)
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| 9. | (英) Neurons (日) (読)
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| 10. | (英) Triazoles (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)
| ○ISSN (任意): | □ | 1347-5215
ISSN: 0918-6158
(pISSN: 0918-6158, eISSN: 1347-5215) Title: Biological & pharmaceutical bulletinTitle(ISO): Biol Pharm BullSupplier: 公益社団法人日本薬学会Publisher: Pharmaceutical Society of Japan (NLM Catalog)
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| ○巻 (必須): | □ | 43
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 1096 1103
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 7月 1日 (令和 2年 7月 1日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1248/bpb.b20-00091 (→Scopusで検索)
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| ○PMID (任意): | □ | 32612072 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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