| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 田原 強 ([徳島大学.先端研究推進センター.バイオイメージング研究部門])
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| ○学籍番号 (推奨): |
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| 2. | (英) Tanaka Masaaki (日) (読)
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| 3. | (英) Nozaki Satoshi (日) (読)
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| 4. | (英) Jin Guanghua (日) (読)
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| 5. | (英) Onoe Hirotaka (日) (読)
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| 6. | (英) Watanabe Yasuyoshi (日) (読)
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| ○題名 (必須): | □ | (英) Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue. (日)
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| ○要約 (任意): | □ | (英) Fatigue can be defined physiologically as inability to maintain the expected power output. At present, no standard of fatigue are yet available. In order to find biomarkers of fatigue, we investigated the level of delta-aminolevulinic acid (ALA), the first intermediate metabolite in the heme biosynthetic pathway, in the plasma and urine of an animal model of fatigue. To prepare fatigued animals, we kept rats for 5 days in a cage filled with water to a height of 1.5 cm. As a result, the plasma and urinary ALA levels were increased in the fatigued animals as compared with those in the control animals. One day after the rats had been returned to their normal cages, these increased levels were restored to the control ones. We also examined the activity of the enzyme ALA dehydratase (ALAD), which is the second enzyme in the heme biosynthetic pathway, and ALAD gene expression during the fatigue and its recovery sessions. The ALAD activity, as well as its gene expression, in the liver of the fatigued animals was decreased as compared with those of the control animals. Both activity and gene expression of ALAD were recovered to their respective control levels after the rats had been allowed to rest in their normal cages for 1 day. Furthermore, the activity of ALA synthase (ALAS), the rate-limiting enzyme in the heme biosynthesis, in the liver was increased after the fatigue session for 5 days. Although this level of increase in the plasma concentration of ALA may not induce fatigue, increase in plasma and urinary ALA levels can be biomarkers of fatigue. (日)
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| ○キーワード (推奨): | 1. | (英) 5-Aminolevulinate Synthetase (日) (読)
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| 2. | (英) Aminolevulinic Acid (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Disease Models, Animal (日) (読)
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| 5. | (英) Fatigue (日) (読)
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| 6. | (英) Gene Expression Regulation, Enzymologic (日) (読)
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| 7. | (英) Liver (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Porphobilinogen Synthase (日) (読)
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| 10. | (英) RNA, Messenger (日) (読)
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| 11. | (英) Rats (日) (読)
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| 12. | (英) Rats, Sprague-Dawley (日) (読)
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| 13. | (英) Recovery of Function (日) (読)
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| 14. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 0006-291X
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 353
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 1068 1073
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| ○年月日 (必須): | □ | 西暦 2006年 12月 28日 (平成 18年 12月 28日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbrc.2006.12.139 (→Scopusで検索)
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| ○PMID (任意): | □ | 17204241 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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