| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Iwata Takayuki (日) (読)
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| 2. | (英) Tanaka Katsunori (日) (読)
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| 3. | 田原 強 ([徳島大学.先端研究推進センター.バイオイメージング研究部門])
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| ○貢献度 (任意): |
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| 4. | (英) Nozaki Satoshi (日) (読)
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| 5. | (英) Onoe Hirotaka (日) (読)
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| 6. | (英) Watanabe Yasuyoshi (日) (読)
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| 7. | (英) Fukase Koichi (日) (読)
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| ○題名 (必須): | □ | (英) A conformationally fixed analog of the peptide mimic Grb2-SH2 domain: synthesis and evaluation against the A431 cancer cell. (日)
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| ○要約 (任意): | □ | (英) A small peptide mimic of the Grb2-SH2 domain, which was previously prepared through the template-assisted click approach and exhibited selective A431 tumor growth inhibition both in vitro and in vivo, was further elaborated on to enhance the interaction with target phosphorylated proteins. A conformationally fixed analog was efficiently synthesized by solid-supported ring-closing metathesis and Cu(i)/His-mediated self-activating Huisgen [3+2] cycloadditon as the key steps, and exhibited a 10-fold enhanced affinity to a phosphorylated peptide, a truncated peptide analog of the Grb2-SH2-interacting phosphoproteins. A stronger interaction with the target phosphorylated proteins gave this cyclic analog cytotoxic activity in A431 cells. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Binding, Competitive (日) (読)
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| 3. | (英) Cell Line, Tumor (日) (読)
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| 4. | (英) Cell Survival (日) (読)
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| 5. | (英) Chemistry Techniques, Synthetic (日) (読)
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| 6. | (英) Cyclization (日) (読)
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| 7. | (英) Dose-Response Relationship, Drug (日) (読)
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| 8. | (英) GRB2 Adaptor Protein (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Mice (日) (読)
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| 11. | (英) Mice, Inbred BALB C (日) (読)
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| 12. | (英) Mice, Nude (日) (読)
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| 13. | (英) Models, Chemical (日) (読)
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| 14. | (英) Molecular Mimicry (日) (読)
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| 15. | (英) Molecular Structure (日) (読)
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| 16. | (英) Neoplasms (日) (読)
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| 17. | (英) Peptides (日) (読)
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| 18. | (英) Peptides, Cyclic (日) (読)
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| 19. | (英) Phosphoproteins (日) (読)
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| 20. | (英) Protein Conformation (日) (読)
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| 21. | (英) Xenograft Model Antitumor Assays (日) (読)
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| 22. | (英) src Homology Domains (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Molecular BioSystems ([英国王立化学会])
(pISSN: 1742-206X, eISSN: 1742-2051)
| ○ISSN (任意): | □ | 1742-2051
ISSN: 1742-206X
(pISSN: 1742-206X, eISSN: 1742-2051) Title: Molecular bioSystemsTitle(ISO): Mol BiosystPublisher: Royal Society of Chemistry (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 9
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 1019 1025
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2013年 5月 初日 (平成 25年 5月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1039/c3mb25462c (→Scopusで検索)
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| ○PMID (任意): | □ | 23403766 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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