| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Tsutsui Ayumi (日) (読)
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| 2. | (英) Ogura Akihiro (日) (読)
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| 3. | 田原 強 ([徳島大学.先端研究推進センター.バイオイメージング研究部門])
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| 4. | (英) Nozaki Satoshi (日) (読)
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| 5. | (英) Urano Sayaka (日) (読)
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| 6. | (英) Hara Mitsuko (日) (読)
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| 7. | (英) Kojima Soichi (日) (読)
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| 8. | (英) Kurbangalieva Almira (日) (読)
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| 9. | (英) Onoe Hirotaka (日) (読)
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| 10. | (英) Watanabe Yasuyoshi (日) (読)
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| 11. | (英) Taniguchi Naoyuki (日) (読)
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| 12. | (英) Tanaka Katsunori (日) (読)
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| ○題名 (必須): | □ | (英) In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice. (日)
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| ○要約 (任意): | □ | (英) Advanced glycation end products (AGEs) are associated with various diseases, especially during aging and the development of diabetes and uremia. To better understand these biological processes, investigation of the in vivo kinetics of AGEs, i.e., analysis of trafficking and clearance properties, was carried out by molecular imaging. Following the preparation of Cy7.5-labeled AGE-albumin and intravenous injection in BALB/cA-nu/nu mice, noninvasive fluorescence kinetics analysis was performed. In vivo imaging and fluorescence microscopy analysis revealed that non-enzymatic AGEs were smoothly captured by scavenger cells in the liver, i.e., Kupffer and other sinusoidal cells, but were unable to be properly cleared from the body. Overall, these results highlight an important link between AGEs and various disorders associated with them, which may serve as a platform for future research to better understand the processes and mechanisms of these disorders. (日)
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| ○キーワード (推奨): | 1. | (英) Albumins (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Fluorescence (日) (読)
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| 4. | (英) Glycation End Products, Advanced (日) (読)
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| 5. | (英) Injections, Intravenous (日) (読)
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| 6. | (英) Kinetics (日) (読)
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| 7. | (英) Liver (日) (読)
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| 8. | (英) Mice (日) (読)
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| 9. | (英) Mice, Inbred BALB C (日) (読)
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| 10. | (英) Mice, Nude (日) (読)
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| 11. | (英) Molecular Imaging (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Organic & Biomolecular Chemistry ([英国王立化学会])
(pISSN: 1477-0520, eISSN: 1477-0539)
| ○ISSN (任意): | □ | 1477-0539
ISSN: 1477-0520
(pISSN: 1477-0520, eISSN: 1477-0539) Title: Organic & biomolecular chemistryTitle(ISO): Org Biomol ChemPublisher: Royal Society of Chemistry (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 14
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| ○号 (必須): | □ | 24
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| ○頁 (必須): | □ | 5755 5760
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 15日 (平成 28年 6月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1039/c6ob00098c (→Scopusで検索)
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| ○PMID (任意): | □ | 26932508 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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