『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=377923EID:377923, Map:0, LastModified:2021年8月10日(火) 13:05:46, Operator:[大家 隆弘], Avail:TRUE, Censor:承認済, Owner:[田原 強], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
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○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Nishimura Kaneyasu (日) (読)
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○学籍番号 (推奨):
[継承]
2. (英) Doi Daisuke (日) (読)
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○学籍番号 (推奨):
[継承]
3. (英) Samata Bumpei (日) (読)
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○学籍番号 (推奨):
[継承]
4. (英) Murayama Shigeo (日) (読)
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○学籍番号 (推奨):
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5.田原 強 ([徳島大学.先端研究推進センター.バイオイメージング研究部門])
○役割 (任意):
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○学籍番号 (推奨):
[継承]
6. (英) Onoe Hirotaka (日) (読)
○役割 (任意):
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○学籍番号 (推奨):
[継承]
7. (英) Takahashi Jun (日) (読)
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○学籍番号 (推奨):
[継承]
○題名 (必須): □(英) Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) For cell transplantation therapy for Parkinson's disease (PD) to be realized, the grafted neurons should be integrated into the host neuronal circuit to restore the lost neuronal function. Here, using wheat-germ agglutinin-based transsynaptic tracing, we show that integrin α5 is selectively expressed in striatal neurons that are innervated by midbrain dopaminergic (DA) neurons. In addition, we found that integrin α5β1 was activated by the administration of estradiol-2-benzoate (E2B) in striatal neurons of adult female rats. Importantly, we observed that the systemic administration of E2B into hemi-parkinsonian rat models facilitates the functional integration of grafted DA neurons derived from human induced pluripotent stem cells into the host striatal neuronal circuit via the activation of integrin α5β1. Finally, methamphetamine-induced abnormal rotation was recovered earlier in E2B-administered rats than in rats that received other regimens. Our results suggest that the simultaneous administration of E2B with stem cell-derived DA progenitors can enhance the efficacy of cell transplantation therapy for PD.  (日)    [継承]
○キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Corpus Striatum (日) (読) [継承]
6. (英) Dopaminergic Neurons (日) (読) [継承]
7. (英) Estradiol (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Gene Expression Profiling (日) (読) [継承]
10. (英) HEK293 Cells (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Induced Pluripotent Stem Cells (日) (読) [継承]
13. (英) Integrin alpha5beta1 (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Methamphetamine (日) (読) [継承]
16. (英) Mice, Inbred C57BL (日) (読) [継承]
17. (英) Microscopy, Confocal (日) (読) [継承]
18. (英) Nerve Net (日) (読) [継承]
19. (英) Neural Stem Cells (日) (読) [継承]
20. (英) Oxidopamine (日) (読) [継承]
21. (英) Parkinson Disease, Secondary (日) (読) [継承]
22. (英) Rats, Inbred F344 (日) (読) [継承]
23. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
24. (英) Stem Cell Transplantation (日) (読) [継承]
25. (英) Transplantation, Heterologous (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Stem Cell Reports (International Society for Stem Cell Research)
(eISSN: 2213-6711)

○ISSN (任意): □2213-6711
ISSN: 2213-6711 (eISSN: 2213-6711)
Title: Stem cell reports
Title(ISO): Stem Cell Reports
Publisher: Cell Press
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □6 [継承]
○号 (必須): □4 [継承]
○頁 (必須): □511 524 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2016年 3月 17日 (平成 28年 3月 17日) [継承]
○URL (任意):
○DOI (任意): □10.1016/j.stemcr.2016.02.008    (→Scopusで検索) [継承]
○PMID (任意): □26997644    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kaneyasu Nishimura, Daisuke Doi, Bumpei Samata, Shigeo Murayama, Tsuyoshi Tahara, Hirotaka Onoe and Jun Takahashi : Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1., Stem Cell Reports, Vol.6, No.4, 511-524, 2016.
欧文冊子 ● Kaneyasu Nishimura, Daisuke Doi, Bumpei Samata, Shigeo Murayama, Tsuyoshi Tahara, Hirotaka Onoe and Jun Takahashi : Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1., Stem Cell Reports, Vol.6, No.4, 511-524, 2016.

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