| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 田原 強 ([徳島大学.先端研究推進センター.バイオイメージング研究部門])
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| 2. | (英) Zhang Zhouen (日) (読)
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| 3. | (英) Ohno Masahiro (日) (読)
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| 4. | (英) Hirao Yukako (日) (読)
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| 5. | (英) Hosaka Nami (日) (読)
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| 6. | (英) Doi Hisashi (日) (読)
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| 7. | (英) Suzuki Masaaki (日) (読)
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| 8. | (英) Onoe Hirotaka (日) (読)
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| ○題名 (必須): | □ | (英) A novel (11)C-labeled thymidine analog, [(11)C]AZT, for tumor imaging by positron emission tomography. (日)
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| ○要約 (任意): | □ | (英) Tumors can be detected by PET using [(11)C]AZT; therefore, [(11)C]AZT could be useful as a novel PET tracer for tumor imaging in vivo. (日) In PET studies, C6 and HeLa tumors in mice were clearly visualized using [(11)C]AZT. Time-activity curves using [(11)C]AZT showed that the accumulation of radioactivity in tumors plateaued at 10 min after injection and persisted for 60 min, while most of the radioactivity in other tissues was rapidly excreted into the urine. In various tissues of the body, tumor tissue showed the highest radioactivity at 80 min after injection (five to six times higher uptake than that of blood). Compared with tumor tissue, uptake was lower in other proliferative tissues such as the spleen, intestine, and bone marrow, resulting in a high tumor-to-bone marrow ratio. Cellular uptake of [(11)C]AZT in C6 cells was completely blocked by the application of thymidine, strongly indicating the specific involvement of nucleoside transporters. In contrast, the time-activity curve of [(11)C]d4T in the tumor showed transient and rapid excretion with almost no obvious tumor tissue accumulation.
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | EJNMMI Research (Springer Berlin)
(eISSN: 2191-219X)
| ○ISSN (任意): | □ | 2191-219X
ISSN: 2191-219X
(eISSN: 2191-219X) Title: EJNMMI researchTitle(ISO): EJNMMI ResPublisher: Springer (NLM Catalog)
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| ○巻 (必須): | □ | 5
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ |
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| ○年月日 (必須): | □ | 西暦 2015年 9月 4日 (平成 27年 9月 4日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s13550-015-0124-0 (→Scopusで検索)
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| ○PMID (任意): | □ | 26337804 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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