| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | (英) Vong Kenward (日) (読)
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| 2. | 田原 強 ([徳島大学.先端研究推進センター.バイオイメージング研究部門])
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| 3. | (英) Urano Sayaka (日) (読)
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| 4. | (英) Nasibullin Igor (日) (読)
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| 5. | (英) Tsubokura Kazuki (日) (読)
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| 6. | (英) Nakao Yoichi (日) (読)
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| 7. | (英) Kurbangalieva Almira (日) (読)
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| 8. | (英) Onoe Hirotaka (日) (読)
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| 9. | (英) Watanabe Yasuyoshi (日) (読)
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| 10. | (英) Tanaka Katsunori (日) (読)
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| ○題名 (必須): | □ | (英) Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy. (日)
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| ○要約 (任意): | □ | (英) This study presents the early framework of selective cell tagging (SeCT) therapy, which is the concept of preferentially labeling specific cells in vivo with chemical moieties that can elicit a therapeutic response. Using glycosylated artificial metalloenzyme (GArM)-based protein labeling, this study reports two separate functional strategies. In one approach, early tumor onset can be suppressed by tagging cancer cells in living mice with an integrin-blocking cyclic-Arg-Gly-Asp (cRGD) moiety, thereby disrupting cell adhesion onto the extracellular matrix. In another approach, tumor growth in mice can be reduced by tagging with a cytotoxic doxorubicin moiety. Subsequent cell death occurs following internalization and drug release. Overall, experiments have shown that mouse populations receiving the mixture of SeCT labeling reagents exhibited a significant delay/reduction in tumor onset and growth compared with controls. Highlighting its adaptability, this work represents a foundational step for further development of SeCT therapy and its potential therapeutic applications. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Science Advances (American Association for the Advancement of Science)
(eISSN: 2375-2548)
| ○ISSN (任意): | □ | 2375-2548
ISSN: 2375-2548
(eISSN: 2375-2548) Title: Science advancesTitle(ISO): Sci AdvPublisher: American Association for the Advancement of Science (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ | 17
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| ○頁 (必須): | □ |
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| ○年月日 (必須): | □ | 西暦 2021年 4月 23日 (令和 3年 4月 23日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1126/sciadv.abg4038 (→Scopusで検索)
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| ○PMID (任意): | □ | 33893089 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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