『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=377727)

EID=377727EID:377727, Map:0, LastModified:2022年6月30日(木) 13:32:19, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[後藤 正和], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1.井上 聖也 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.食道・乳腺甲状腺外科])
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
2.吉田 卓弘
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
3.西野 豪志
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
4.後藤 正和 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
5.青山 万理子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
6.河北 直也 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.呼吸器外科])
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
7.山本 洋太
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
8.古北 由仁
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨): □**** [ユーザ]
[継承]
9.滝沢 宏光 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学]/[徳島大学.病院.診療科.外科.呼吸器外科])
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
10.丹黒 章
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
○題名 (必須): □(英) Biomarkers predicting the response to chemotherapy and the prognosis in patients with esophageal squamous cell carcinoma.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) The prognosis of patients with esophageal squamous cell carcinoma (ESCC) has been improved by multidisciplinary therapy with chemoradiotherapy and surgery, but it remains poor. Advanced stage, malignant potential, and chemo-resistance contribute to the poor prognosis. Here, we attempted to identify predictive factors of the response to chemotherapy and the prognosis of ESCC patients. We examined 51 ESCC patients who were treated with chemotherapy followed by radical surgery, and 23 patients who were treated with chemotherapy alone. We conducted quantitative reverse transcription-polymerase chain reaction gene expression analysis using RNA extracted from 74 tumor tissue samples collected before chemotherapy and 67 tumor tissue samples collected after chemotherapy, focusing on PIK3CA, AKT-1, mTOR, 4E-BP1, p70S6K, PD-L1, and PD-L2. The proportions of patients with high expressions of AKT-1 and PD-L1 before chemotherapy were significantly higher among the non-responders than among the responders (p = 0.034, p = 0.020, respectively). Multivariate analyses revealed that high PD-L1 expression before chemotherapy was associated with poor response to chemotherapy (odds ratio 2.998; 95% CI 1.043-8.619; p = 0.042) and high p70S6K expression before chemotherapy was a poor prognostic factor (hazard ratio 2.518; 95% CI 1.058-5.988; p = 0.037). In addition, the patients with high expression of PD-L1 and PD-L2 in the tumors after chemotherapy had significantly worse survival than those with low expression of these genes (p = 0.012, p = 0.007, respectively). These results demonstrated that PD-L1 and p70S6K in the primary ESCC tissues were related to a poor response to chemotherapy and poor prognosis, respectively.  (日)    [継承]
○キーワード (推奨): 1. (英) Biomarkers, Tumor (日) (読) [継承]
2. (英) Chemoradiotherapy (日) (読) [継承]
3. (英) Esophageal Neoplasms (日) (読) [継承]
4. (英) Esophageal Squamous Cell Carcinoma (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Prognosis (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □General Thoracic and Cardiovascular Surgery ([特定非営利活動法人 日本胸部外科学会])
(pISSN: 1863-6705, eISSN: 1863-6713)

○ISSN (任意): □1863-6713
ISSN: 1863-6705 (pISSN: 1863-6705, eISSN: 1863-6713)
Title: General thoracic and cardiovascular surgery
Title(ISO): Gen Thorac Cardiovasc Surg
Publisher: Springer
 (NLM Catalog)   (医中誌Web)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
[継承]
[継承]
○巻 (必須): □69 [継承]
○号 (必須): □3 [継承]
○頁 (必須): □525 533 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2021年 1月 15日 (令和 3年 1月 15日) [継承]
○URL (任意):
○DOI (任意): □10.1007/s11748-021-01586-5    (→Scopusで検索) [継承]
○PMID (任意): □33449265    (→Scopusで検索) [継承]
○CRID (任意):
○WOS (任意):
○Scopus (任意): □2-s2.0-85099215910 [継承]
○評価値 (任意):
○被引用数 (任意):
○指導教員 (推奨):
○備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Seiya Inoue, Takahiro Yoshida, Takeshi Nishino, Masakazu Goto, Mariko Aoyama, Naoya Kawakita, Yota Yamamoto, Yoshihito Furukita, Hiromitsu Takizawa and Akira Tangoku : Biomarkers predicting the response to chemotherapy and the prognosis in patients with esophageal squamous cell carcinoma., General Thoracic and Cardiovascular Surgery, Vol.69, No.3, 525-533, 2021.
欧文冊子 ● Seiya Inoue, Takahiro Yoshida, Takeshi Nishino, Masakazu Goto, Mariko Aoyama, Naoya Kawakita, Yota Yamamoto, Yoshihito Furukita, Hiromitsu Takizawa and Akira Tangoku : Biomarkers predicting the response to chemotherapy and the prognosis in patients with esophageal squamous cell carcinoma., General Thoracic and Cardiovascular Surgery, Vol.69, No.3, 525-533, 2021.

関連情報

Number of session users = 0, LA = 0.79, Max(EID) = 404178, Max(EOID) = 1094807.