『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (紀要その他) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1.寺奥 大貴 ([徳島大学.病院.中央診療施設等.周産母子センター])
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2.森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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3.宇山 直人
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4.池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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5.岩橋 衆一
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6.齋藤 裕 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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7.髙須 千絵 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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8.居村 暁
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9.原田 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])
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10.島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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○題名 (必須): □(英) Role of Central Hypo-enhancement in the Hepatic Arterial Phase of Dynamic Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) The enhancement pattern in the hepatic arterial phase (HAP) of dynamic computed tomography (CT) is reportedly a prognostic marker in patients with intrahepatic cholangiocarcinoma (IHCC). This study was performed to clarify the significance of central hypo-enhancement in the HAP in patients with mass-forming IHCC. Forty patients who had undergone initial surgical resection for mass-forming IHCC were enrolled. The dynamic CT was scanned 40 s after contrast agent injection as the HAP. A radiologist classified the patients into three groups based on the vascular pattern: the hyper-enhancement group (Hyper group), rim-enhancement group (Rim group), and hypo-enhancement group (Hypo group). The surgical specimens were immunohistochemically stained for hypoxia-inducible factor 1 (HIF-1). The correlation with clinicopathological findings and HIF-1 expression was investigated. The Hyper, Rim, and Hypo groups comprised 8, 7, and 25 patients, respectively. There were no significant correlations between the groups and clinicopathological factors. Overall survival (OS) was significantly worse in the Hypo than in the Hyper group (p = 0.03). OS was also significantly worse in the Rim +ypo group (i.e., hypo-enhancement in the central tumor) than in the Hyper group (p = 0.04). Furthermore, inclusion in the Rim +ypo group was a prognostic factor for OS (hazard ratio 6.68). High HIF-1 expression in the central part of the tumor was correlated with central hypo-enhancement (Hyper group: 25% and Rim +ypo group: 72%). Central hypo-enhancement was a prognostic factor in patients with IHCC. The high malignant potential of tumors with central hypo-enhancement might be associated with HIF-1 upregulation.  (日)    [継承]
○キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Bile Duct Neoplasms (日) (読) [継承]
4. (英) Bile Ducts, Intrahepatic (日) (読) [継承]
5. (英) Biomarkers, Tumor (日) (読) [継承]
6. (英) Cholangiocarcinoma (日) (読) [継承]
7. (英) Contrast Media (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Follow-Up Studies (日) (読) [継承]
10. (英) Hepatectomy (日) (読) [継承]
11. (英) Hepatic Artery (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13. (英) Hypoxia-Inducible Factor 1, alpha Subunit (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Middle Aged (日) (読) [継承]
16. (英) Multidetector Computed Tomography (日) (読) [継承]
17. (英) Prognosis (日) (読) [継承]
18. (英) Proportional Hazards Models (日) (読) [継承]
19. (英) Retrospective Studies (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □World Journal of Surgery (International Society of Surgery)
(pISSN: 0364-2313, eISSN: 1432-2323)

○ISSN (任意): □1432-2323
ISSN: 0364-2313 (pISSN: 0364-2313, eISSN: 1432-2323)
Title: World journal of surgery
Title(ISO): World J Surg
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □44 [継承]
○号 (必須): □7 [継承]
○頁 (必須): □2350 2358 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2020年 7月 初日 (令和 2年 7月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1007/s00268-020-05456-8    (→Scopusで検索) [継承]
○PMID (任意): □32152739    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) Article.ELocationID: 10.1007/s00268-020-05456-8  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hiroki Teraoku, Yuji Morine, Naoto Uyama, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Satoru Imura, Masafumi Harada and Mitsuo Shimada : Role of Central Hypo-enhancement in the Hepatic Arterial Phase of Dynamic Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma., World Journal of Surgery, Vol.44, No.7, 2350-2358, 2020.
欧文冊子 ● Hiroki Teraoku, Yuji Morine, Naoto Uyama, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Satoru Imura, Masafumi Harada and Mitsuo Shimada : Role of Central Hypo-enhancement in the Hepatic Arterial Phase of Dynamic Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma., World Journal of Surgery, Vol.44, No.7, 2350-2358, 2020.

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