| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 佐々木 由紀 ([徳島大学.AWAサポートセンター])
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| 2. | 大塚 邦紘 ([徳島大学.病院.先端歯科医療開発研究プロジェクト]/[徳島大学.病院.診療科.歯科口腔外科.口腔外科])
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| 3. | 有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 4. | 九十九 伸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 5. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○題名 (必須): | □ | (英) Distinct Roles of IL-1 and IL-18 in NLRC4-Induced Autoinflammation. (日)
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| ○要約 (任意): | □ | (英) The NLRC4 inflammasome assembles in response to detection of bacterial invasion, and NLRC4 activation leads to the production of IL-1 and IL-18 together with pyroptosis-mediated cell death. Missense activating mutations in cause autoinflammatory disorders whose symptoms are distinctly dependent on the site of mutation and other aspects of the genetic background. To determine the involvement of IL-1 and IL-18 in the inflammation induced by mutation, we depleted IL-1 , IL-18, or both cytokines in Nlrc4-transgenic mice in which mutant is expressed under the MHC class II promoter (Nlrc4-H443P-Tg mice). The deletion of the or gene in Nlrc4-H443P-Tg mice reduced the neutrophil numbers in the spleen, and mice with deletion of both genes had an equivalent number of neutrophils compared to wild-type mice. Deletion of ameliorated but did not eliminate bone marrow hyperplasia, while mice deficient in showed no bone marrow hyperplasia. In contrast, tail bone deformity remained in the presence of deficiency, but deficiency completely abolished bone deformity. The decreased bone density in Nlrc4-H443P-Tg mice was counteracted by but not deficiency. Our results demonstrate the distinct effects of IL-1 and IL-18 on NLRC4-induced inflammation among tissues, which suggests that blockers for each cytokine should be utilized depending on the site of inflammation. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Frontiers in Immunology (Frontiers Research Foundation)
(eISSN: 1664-3224)
| ○ISSN (任意): | □ | 1664-3224
ISSN: 1664-3224
(eISSN: 1664-3224) Title: Frontiers in immunologyTitle(ISO): Front ImmunolPublisher: Frontiers Media SA (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 11
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| ○号 (必須): |
| ○頁 (必須): | □ | 591713 591713
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| ○年月日 (必須): | □ | 西暦 2020年 10月 14日 (令和 2年 10月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3389/fimmu.2020.591713 (→Scopusで検索)
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| ○PMID (任意): | □ | 33178225 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-85094604314
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3389/fimmu.2020.591713 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: NLRC4 (日)
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| 4. | (英) KeywordList.Keyword: autoinflammation (日)
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| 5. | (英) KeywordList.Keyword: bone (日)
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| 6. | (英) KeywordList.Keyword: interleukin-18 (日)
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| 7. | (英) KeywordList.Keyword: interleukin-1 (日)
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