| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nakashima Shota (日) (読)
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| 2. | (英) Kakugawa Tomoyuki (日) (読)
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| 3. | (英) Yura Hirokazu (日) (読)
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| 4. | (英) Tomonaga Masaomi (日) (読)
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| 5. | (英) Harada Tatsuhiko (日) (読)
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| 6. | (英) Hara Atsuko (日) (読)
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| 7. | (英) Hara Shintaro (日) (読)
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| 8. | (英) Nakano Masayuki (日) (読)
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| 9. | (英) Yamasaki Eiki (日) (読)
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| 10. | (英) Sakamoto Noriho (日) (読)
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| 11. | (英) Ishimatsu Yuji (日) (読)
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| 12. | (英) Isomoto Hajime (日) (読)
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| 13. | (英) Gochuico R. Bernadette (日) (読)
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| 14. | (英) Suffredini F. Anthony (日) (読)
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| 15. | (英) Mukae Hiroshi (日) (読)
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| 16. | 倉園 久生
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| 17. | (英) Hirayama Toshiya (日) (読)
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| 18. | (英) Moss Joel (日) (読)
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| 19. | (英) Kohno Shigeru (日) (読)
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| ○題名 (必須): | □ | (英) Identification of Helicobacter pylori VacA in human lung and its effects on lung cells. (日)
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| ○要約 (任意): | □ | (英) Prior reports suggested that infection with Helicobacter pylori was associated with respiratory diseases; pathogenetic mechanisms however, were not defined. We tested the hypothesis that VacA, an exotoxin of H. pylori, a gastric pathogen, was aspirated into the lung and could stimulate secretion of inflammatory cytokines by lung epithelial cells. The presence of VacA was determined by immunohistochemistry in surgical lung biopsy tissue samples from 72 patients with interstitial pneumonia. The effects of VacA on A549 human alveolar epithelial adenocarcinoma cells and normal human bronchial epithelial cells were determined. After incubation with VacA, the secretions of cytokines were measured by Multiplex Luminex(®) Assays. VacA was detected with anti-VacA antibodies in bronchial epithelial cells and alveolar epithelial cells from 10 of 72 patients with interstitial pneumonia. VacA was more prevalent in lungs of patients with collagen vascular disease-associated interstitial pneumonia than in those of patients with idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia and cryptogenic organizing pneumonia. Incubation of A549 cells and normal human bronchial epithelial cells with VacA for 24 h was cytotoxic, and resulted in vacuolation. VacA induced interleukin-8 production by A549 cells and normal human bronchial epithelial cells and interleukin-6 production by A549 cells. Based on multiplex screening, interleukin-8 and interleukin-6 were the primary secretory products induced by VacA. H. pylori VacA is present in human lung and can induce interleukin-8 and interleukin-6 production by human lung cells. VacA could have a role in the pathogenesis of respiratory diseases by its cytotoxic effects and by inducing the secretion of interleukin-8 and interleukin-6 by targeted airway epithelial cells. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Bacterial Proteins (日) (読)
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| 4. | (英) Cell Line, Tumor (日) (読)
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| 5. | (英) Cells, Cultured (日) (読)
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| 6. | 細胞質分裂 (cytokinesis)
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| 7. | 女性 (female)
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| 8. | (英) Helicobacter pylori (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Lung (日) (読)
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| 11. | 男性 (male)
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| 12. | (英) Middle Aged (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 1090-2104
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 460
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 721 726
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 3月 25日 (平成 27年 3月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbrc.2015.03.096 (→Scopusで検索)
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| ○PMID (任意): | □ | 25817795 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-84937765224
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: S0006-291X(15)00552-5 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.bbrc.2015.03.096 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Intramural (日)
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| 5. | (英) KeywordList.Keyword: A549 cells (日)
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| 6. | (英) KeywordList.Keyword: Helicobacter pylori (日)
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| 7. | (英) KeywordList.Keyword: Interleukin-6 (日)
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| 8. | (英) KeywordList.Keyword: Interleukin-8 (日)
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| 9. | (英) KeywordList.Keyword: Normal human bronchial epithelial cells (日)
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| 10. | (英) KeywordList.Keyword: VacA (日)
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