『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=372987)

EID=372987EID:372987, Map:0, LastModified:2020年12月24日(木) 10:35:21, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[倉園 久生], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Chaisri U (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Nagata M (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.倉園 久生 ([徳島大学.研究支援・産官学連携センター])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Horie H (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Tongtawe P (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Hayashi H (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Watanabe T (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Tapchaisri P (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Chongsa-nguan M (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Chaicumpa W (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Localization of Shiga toxins of enterohaemorrhagic Escherichia coli in kidneys of paediatric and geriatric patients with fatal haemolytic uraemic syndrome.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and renal failure. Infection with enterohaemorrhagic Escherichia coli (EHEC), mainly O157:H7, has been strongly implicated as the major cause of HUS in children. The pathogenesis of HUS caused by the infection is not well understood and the defined sites of Stx in kidney of EHEC-infected humans has not been clearly demonstrated. The aim of this study was to investigate and compare the locations of Stx deposition in kidneys of paediatric and geriatric patients who died from enterohaemorrhagic E. coli O157 (EHEC) associated HUS, using an immunoperoxidase staining of the tissues. The study revealed that binding of Stx was relatively less and limited only to the renal tubules of an adult case (81 years old), while more binding was found at both renal tubules and glomeruli of an infant case (21 months old). The Stx binding in the infant's glomeruli was at podocytes, mesangial and endothelial cells. It has been known that young children are more susceptible than adults to HUS. One possibility for this is that the more extensive binding of the Stx to the kidney tissue of the paediatric patient might be due to the higher synthesis and expression of Stx receptors, i.e. Gb(3), in infants and less so in the aged individuals. However, other alternatives are possible, for example, the difference in stage of HUS in individual patients. Thus it is too early to draw any conclusion on this enigma and further investigation is required.  (日)    [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Aged, 80 and over (日) (読) [継承]
3. (英) Escherichia coli Infections (日) (読) [継承]
4. (英) Escherichia coli O157 (日) (読) [継承]
5. (英) Fatal Outcome (日) (読) [継承]
6.女性 (female) [継承]
7. (英) Hemolytic-Uremic Syndrome (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9.免疫組織化学 (immunohistochemistry) [継承]
10.小児 (infant) [継承]
11. (英) Kidney (日) (読) [継承]
12. (英) Necrosis (日) (読) [継承]
13. (英) Shiga Toxins (日) (読) [継承]
14. (英) Staining and Labeling (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Microbial Pathogenesis ([Elsevier])
(pISSN: 0882-4010, eISSN: 1096-1208)

ISSN (任意): 0882-4010
ISSN: 0882-4010 (pISSN: 0882-4010, eISSN: 1096-1208)
Title: Microbial pathogenesis
Title(ISO): Microb Pathog
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 31 [継承]
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(必須): 59 67 [継承]
都市 (任意):
年月日 (必須): 西暦 2001年 8月 初日 (平成 13年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.1006/mpat.2001.0447    (→Scopusで検索) [継承]
PMID (任意): 11453701    (→Scopusで検索) [継承]
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WOS (任意):
Scopus (任意): 2-s2.0-0034924996 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Case Reports  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● U Chaisri, M Nagata, Hisao Kurazono, H Horie, P Tongtawe, H Hayashi, T Watanabe, P Tapchaisri, M Chongsa-nguan and W Chaicumpa : Localization of Shiga toxins of enterohaemorrhagic Escherichia coli in kidneys of paediatric and geriatric patients with fatal haemolytic uraemic syndrome., Microbial Pathogenesis, Vol.31, No.2, 59-67, 2001.
欧文冊子 ● U Chaisri, M Nagata, Hisao Kurazono, H Horie, P Tongtawe, H Hayashi, T Watanabe, P Tapchaisri, M Chongsa-nguan and W Chaicumpa : Localization of Shiga toxins of enterohaemorrhagic Escherichia coli in kidneys of paediatric and geriatric patients with fatal haemolytic uraemic syndrome., Microbial Pathogenesis, Vol.31, No.2, 59-67, 2001.

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