『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
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○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Yamamoto S (日) (読)
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○学籍番号 (推奨):
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2. (英) Takeda Y (日) (読)
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3. (英) Yamamoto M (日) (読)
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4.倉園 久生
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5. (英) Imaoka K (日) (読)
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6. (英) Yamamoto M (日) (読)
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7. (英) Fujihashi K (日) (読)
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8. (英) Noda M (日) (読)
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9. (英) Kiyono H (日) (読)
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10. (英) McGhee R. J (日) (読)
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○題名 (必須): □(英) Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Cholera toxin (CT), the most commonly used mucosal adjuvant in experimental animals, is unsuitable for humans because of potent diarrhea-inducing properties. We have constructed two CT-A subunit mutants, e.g., serine-->phenylalanine at position 61 (S61F), and glutamic acid-->lysine at 112 (E112K) by site-directed mutagenesis. Neither mutant CT (mCT), in contrast to native CT (nCT), induced adenosine diphosphate-ribosylation, cyclic adenosine monophosphate formation, or fluid accumulation in ligated mouse ileal loops. Both mCTs retained adjuvant properties, since mice given ovalbumin (OVA) subcutaneously with mCTs or nCT, but not OVA alone developed high-titered serum anti-OVA immunoglobulin G (IgG) antibodies (Abs) which were largely of IgG1 and IgG2b subclasses. Although nCT induced brisk IgE Ab responses, both mCTs elicited lower anti-OVA IgE Abs. OVA-specific CD4+ T cells were induced by nCT and by mCTs, and quantitative analysis of secreted cytokines and mRNA revealed a T helper cell 2 (Th2)-type response. These results now show that the toxic properties of CT can be separated from adjuvanticity, and the mCTs induce Ab responses via a Th2 cell pathway.  (日)    [継承]
○キーワード (推奨): 1. (英) Adjuvants, Immunologic (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
4. (英) CHO Cells (日) (読) [継承]
5. (英) Cholera Toxin (日) (読) [継承]
6. (英) Cricetinae (日) (読) [継承]
7. (英) Cyclic AMP (日) (読) [継承]
8.細胞質分裂 (cytokinesis) [継承]
9. (英) Diarrhea (日) (読) [継承]
10. (英) Dose-Response Relationship, Drug (日) (読) [継承]
11. (英) Ileum (日) (読) [継承]
12. (英) Lymphocyte Activation (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, Inbred C57BL (日) (読) [継承]
15. (英) Mucous Membrane (日) (読) [継承]
16. (英) Mutation (日) (読) [継承]
17. (英) Poly(ADP-ribose) Polymerases (日) (読) [継承]
18. (英) Th2 Cells (日) (読) [継承]
19. (英) Toxicity Tests (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □The Journal of Experimental Medicine ([The Rockefeller University Press])
(pISSN: 0022-1007, eISSN: 1540-9538)

○ISSN (任意): □0022-1007
ISSN: 0022-1007 (pISSN: 0022-1007, eISSN: 1540-9538)
Title: The Journal of experimental medicine
Title(ISO): J Exp Med
Publisher: Rockefeller University Press
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □185 [継承]
○号 (必須): □7 [継承]
○頁 (必須): □1203 1210 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1997年 4月 7日 (平成 9年 4月 7日) [継承]
○URL (任意):
○DOI (任意): □10.1084/jem.185.7.1203    (→Scopusで検索) [継承]
○PMID (任意): □9104807    (→Scopusで検索) [継承]
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○Scopus (任意): □2-s2.0-0030902280 [継承]
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○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● S Yamamoto, Y Takeda, M Yamamoto, Hisao Kurazono, K Imaoka, M Yamamoto, K Fujihashi, M Noda, H Kiyono and J R. McGhee : Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity., The Journal of Experimental Medicine, Vol.185, No.7, 1203-1210, 1997.
欧文冊子 ● S Yamamoto, Y Takeda, M Yamamoto, Hisao Kurazono, K Imaoka, M Yamamoto, K Fujihashi, M Noda, H Kiyono and J R. McGhee : Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity., The Journal of Experimental Medicine, Vol.185, No.7, 1203-1210, 1997.

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