『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=372089EID:372089, Map:0, LastModified:2020年10月30日(金) 19:39:44, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[常山 幸一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Leung Patrick S C (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Park Ogyi (日) (読)
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学籍番号 (推奨):
[継承]
3.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
役割 (任意):
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学籍番号 (推奨):
[継承]
4. (英) Kurth Mark J (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Lam Kit S (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Ansari Aftab A (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Coppel Ross L (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Gershwin M Eric (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Although significant advances have been made in dissecting the effector mechanisms in autoimmunity, the major stumbling block remains defining the etiological events that precede disease. Primary biliary cirrhosis (PBC) illustrates this paradigm because of its high degree of heritability, its female predominance, and its extraordinarily specific and defined immune response and target destruction. In PBC, the major autoantigens belong to E2 components of the 2-oxo-acid dehydrogenase family of mitochondrially located enzymes that share a lipoylated peptide sequence that is the immunodominant target. Our previous work has demonstrated that synthetic mimics of the lipoate molecule such as 6-bromohexoanate demonstrate a high degree of reactivity with PBC sera prompted us to immunize groups of guinea pigs with 6-bromohexanoate conjugated to BSA. In this study, we provide serologic and immunohistochemical evidence that such immunized guinea pigs not only develop antimitochondrial autoantibody responses similar to human PBC, but also develop autoimmune cholangitis after 18 mo. Xenobiotic-immunized guinea pigs are the first induced model of PBC and suggest an etiology that has implications for the causation of other human autoimmune diseases. The data also reflect the likelihood that, in PBC, the multilineage antimitochondrial response is a pathogenic mechanism and that loss of tolerance and subsequent development of biliary lesions depends on either modification of the host mitochondrial Ag or a similar breakdown due to molecular mimicry.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autoantibodies (日) (読) [継承]
3. (英) Autoantigens (日) (読) [継承]
4. (英) Autoimmune Diseases (日) (読) [継承]
5. (英) Caproates (日) (読) [継承]
6. (英) Cholangitis (日) (読) [継承]
7. (英) Dihydrolipoyllysine-Residue Acetyltransferase (日) (読) [継承]
8. (英) Disease Models, Animal (日) (読) [継承]
9. (英) Female (日) (読) [継承]
10. (英) Guinea Pigs (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Immune Tolerance (日) (読) [継承]
13. (英) Immunization (日) (読) [継承]
14. (英) Liver Cirrhosis, Biliary (日) (読) [継承]
15. (英) Male (日) (読) [継承]
16. (英) Mitochondria (日) (読) [継承]
17. (英) Mitochondrial Proteins (日) (読) [継承]
18. (英) Molecular Mimicry (日) (読) [継承]
19. (英) Sex Factors (日) (読) [継承]
20. (英) Xenobiotics (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 179 [継承]
(必須): 4 [継承]
(必須): 2651 2657 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 8月 15日 (平成 19年 8月 15日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.179.4.2651    (→Scopusで検索) [継承]
PMID (任意): 17675529    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]

標準的な表示

和文冊子 ● C Patrick S Leung, Ogyi Park, Koichi Tsuneyama, J Mark Kurth, S Kit Lam, A Aftab Ansari, L Ross Coppel and Eric M Gershwin : Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization., The Journal of Immunology, Vol.179, No.4, 2651-2657, 2007.
欧文冊子 ● C Patrick S Leung, Ogyi Park, Koichi Tsuneyama, J Mark Kurth, S Kit Lam, A Aftab Ansari, L Ross Coppel and Eric M Gershwin : Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization., The Journal of Immunology, Vol.179, No.4, 2651-2657, 2007.

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