『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yamamoto Yasuhiko (日) (読)
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[継承]
2. (英) Harashima Ai (日) (読)
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[継承]
3. (英) Saito Hidehito (日) (読)
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[継承]
4.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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[継承]
5. (英) Munesue Seiichi (日) (読)
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[継承]
6. (英) Motoyoshi So (日) (読)
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[継承]
7. (英) Han Dong (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Watanabe Takuo (日) (読)
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[継承]
9. (英) Asano Masahide (日) (読)
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[継承]
10. (英) Takasawa Shin (日) (読)
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[継承]
11. (英) Okamoto Hiroshi (日) (読)
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[継承]
12. (英) Shimura Satoshi (日) (読)
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[継承]
13. (英) Karasawa Tadahiro (日) (読)
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[継承]
14. (英) Yonekura Hideto (日) (読)
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学籍番号 (推奨):
[継承]
15. (英) Yamamoto Hiroshi (日) (読)
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[継承]
題名 (必須): (英) Septic shock is associated with receptor for advanced glycation end products ligation of LPS.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Septic shock is a severe systemic response to bacterial infection. Receptor for advanced glycation end products (RAGE) plays a role in immune reactions to recognize specific molecular patterns as pathogen recognition receptors. However, the interaction between LPS, the bioactive component of bacterial cell walls, and RAGE is unclear. In this study, we found direct LPS binding to RAGE by a surface plasmon resonance assay, a plate competition assay, and flow cytometry. LPS increased TNF-α secretion from peritoneal macrophages and an NF-κB promoter-driven luciferase activity through RAGE. Blood neutrophils and monocytes expressed RAGE, and TLR2 was counterregulated in RAGE(-/-) mice. After LPS injection, RAGE(+/+) mice showed a higher mortality, higher serum levels of IL-6, TNF-α, high mobility group box 1, and endothelin-1, and severe lung and liver pathologies compared with RAGE(-/-) mice without significant differences in plasma LPS level. Administration of soluble RAGE significantly reduced the LPS-induced cytokine release and tissue damage and improved the LPS-induced lethality even in RAGE(-/-) as well as RAGE(+/+) mice. The results thus suggest that RAGE can associate with LPS and that RAGE system can regulate inflammatory responses. Soluble RAGE would be a therapeutic tool for LPS-induced septic shock.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Binding, Competitive (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Glycation End Products, Advanced (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Inflammation Mediators (日) (読) [継承]
8. (英) Ligands (日) (読) [継承]
9. (英) Lipopolysaccharides (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Knockout (日) (読) [継承]
13. (英) Molecular Sequence Data (日) (読) [継承]
14. (英) NF-kappa B (日) (読) [継承]
15. (英) Protein Binding (日) (読) [継承]
16. (英) Rats (日) (読) [継承]
17. (英) Receptor for Advanced Glycation End Products (日) (読) [継承]
18. (英) Receptors, Immunologic (日) (読) [継承]
19. (英) Shock, Septic (日) (読) [継承]
20. (英) Signal Transduction (日) (読) [継承]
21. (英) Survival Analysis (日) (読) [継承]
22. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 186 [継承]
(必須): 5 [継承]
(必須): 3248 3257 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 1月 26日 (平成 23年 1月 26日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1002253    (→Scopusで検索) [継承]
PMID (任意): 21270403    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yasuhiko Yamamoto, Ai Harashima, Hidehito Saito, Koichi Tsuneyama, Seiichi Munesue, So Motoyoshi, Dong Han, Takuo Watanabe, Masahide Asano, Shin Takasawa, Hiroshi Okamoto, Satoshi Shimura, Tadahiro Karasawa, Hideto Yonekura and Hiroshi Yamamoto : Septic shock is associated with receptor for advanced glycation end products ligation of LPS., The Journal of Immunology, Vol.186, No.5, 3248-3257, 2011.
欧文冊子 ● Yasuhiko Yamamoto, Ai Harashima, Hidehito Saito, Koichi Tsuneyama, Seiichi Munesue, So Motoyoshi, Dong Han, Takuo Watanabe, Masahide Asano, Shin Takasawa, Hiroshi Okamoto, Satoshi Shimura, Tadahiro Karasawa, Hideto Yonekura and Hiroshi Yamamoto : Septic shock is associated with receptor for advanced glycation end products ligation of LPS., The Journal of Immunology, Vol.186, No.5, 3248-3257, 2011.

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