『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=372020EID:372020, Map:0, LastModified:2020年10月30日(金) 19:21:01, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[常山 幸一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hashimoto N (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Shimoda S (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kawanaka H (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Uehara H (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Akahoshi T (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Kinjo N (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Taketomi A (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Shirabe K (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Akashi K (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
11. (英) Lleo A (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
12. (英) Ansari A A (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
13. (英) Gershwin M E (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
14. (英) Maehara Y (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Modulation of CD4+ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Dysfunction of T cells is a common feature in chronic persistent viral infections, including hepatitis C virus (HCV), and although hepatic and peripheral T cells have been studied extensively in chronic HCV hepatitis, the role of splenic T cell responses in such patients is poorly defined. This is an important issue, as thrombocytopenia is a complication of HCV-related liver cirrhosis (LC), due to splenic platelet sequestration and bone marrow suppression; splenectomy has been proposed to treat such patients. Herein, we studied peripheral blood mononuclear cells (PBMC) and splenic lymphoid subpopulations from a total of 22 patients, including 15 with HCV-related LC with marked thrombocytopenia treated with splenectomy, and seven controls. CD4(+) T cells from peripheral blood and spleen were isolated and phenotype and function evaluated. Splenic CD4(+) T cells in patients with LC expressed molecules associated with inhibitory signalling, including increased frequency of negative markers such as cytotoxic T lymphocyte associated antigen-4 (CTLA-4) and programmed death 1 (PD-1) and decreased production of cytokines. Patients with LC manifest higher levels of splenic CD4(+) regulatory T cells and PD-L1- and PD-L2-expressing cells than controls. Blocking of PD-1/PD-1 ligand interaction reconstituted proliferative and cytokine responses of splenic mononuclear cells (SMC) from patients with LC. Splenectomy was followed by an increase in the ratio of interferon (IFN)-γ to interleukin (IL)-10 and a reduction of PD-1-expressing CD4(+) T cells in peripheral blood. Our data suggest that peripheral tolerance is promoted by the spleen in LC via the up-regulated expression of PD-1 ligands.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Antigens, CD (日) (読) [継承]
4. (英) Apoptosis Regulatory Proteins (日) (読) [継承]
5. (英) B7-1 Antigen (日) (読) [継承]
6. (英) B7-H1 Antigen (日) (読) [継承]
7. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
8. (英) CTLA-4 Antigen (日) (読) [継承]
9. (英) Cytokines (日) (読) [継承]
10. (英) Female (日) (読) [継承]
11. (英) Flow Cytometry (日) (読) [継承]
12. (英) Hepacivirus (日) (読) [継承]
13. (英) Hepatitis C (日) (読) [継承]
14. (英) Humans (日) (読) [継承]
15. (英) Immune Tolerance (日) (読) [継承]
16. (英) Interferon-gamma (日) (読) [継承]
17. (英) Interleukin-10 (日) (読) [継承]
18. (英) Leukocytes, Mononuclear (日) (読) [継承]
19. (英) Liver Cirrhosis (日) (読) [継承]
20. (英) Lymphocyte Count (日) (読) [継承]
21. (英) Lymphocyte Subsets (日) (読) [継承]
22. (英) Male (日) (読) [継承]
23. (英) Middle Aged (日) (読) [継承]
24. (英) Programmed Cell Death 1 Ligand 2 Protein (日) (読) [継承]
25. (英) Programmed Cell Death 1 Receptor (日) (読) [継承]
26. (英) Spleen (日) (読) [継承]
27. (英) Splenectomy (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 1365-2249
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 165 [継承]
(必須): 2 [継承]
(必須): 243 250 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 5月 25日 (平成 23年 5月 25日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2249.2011.04393.x    (→Scopusで検索) [継承]
PMID (任意): 21615390    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● N Hashimoto, S Shimoda, H Kawanaka, Koichi Tsuneyama, H Uehara, T Akahoshi, N Kinjo, A Taketomi, K Shirabe, K Akashi, A Lleo, A A Ansari, E M Gershwin and Y Maehara : Modulation of CD4+ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis., Clinical and Experimental Immunology, Vol.165, No.2, 243-250, 2011.
欧文冊子 ● N Hashimoto, S Shimoda, H Kawanaka, Koichi Tsuneyama, H Uehara, T Akahoshi, N Kinjo, A Taketomi, K Shirabe, K Akashi, A Lleo, A A Ansari, E M Gershwin and Y Maehara : Modulation of CD4+ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis., Clinical and Experimental Immunology, Vol.165, No.2, 243-250, 2011.

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