『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ambrosini Y M (日) (読)
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[継承]
2. (英) Yang G-X (日) (読)
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[継承]
3. (英) Zhang W (日) (読)
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[継承]
4. (英) Tsuda M (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Shu S (日) (読)
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学籍番号 (推奨):
[継承]
6.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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学籍番号 (推奨):
[継承]
7. (英) Leung P S C (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Ansari A A (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Coppel R L (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Gershwin M E (日) (読)
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[継承]
題名 (必須): (英) The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) A void in understanding primary biliary cirrhosis (PBC) is the absence of appropriate animal models. Our laboratory has studied a murine model of autoimmune cholangitis induced following immunization with 2-octynoic acid (2OA), an antigen identified following extensive quantitative structural activity relationship (QSAR) analysis, using human autoantibodies and three-dimensional analysis of the mitochondrial autoantigen, the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2). Mice immunized with 2OA coupled to bovine serum albumin (BSA) develop anti-mitochondrial antibodies (AMAs) of the identical specificity as humans with PBC, and in addition develop inflammatory portal cell infiltrates in liver. However, the natural history of disease is less severe than in humans and does not include fibrosis. Data from human and autoimmune murine models suggest that environmental and/or infectious agents can exacerbate autoimmune reactions, and a model of PBC has been described in which polyinosinic-polycytidylic acid (poly I:C), a viral RNA mimetic and Toll-like receptor 3 (TLR-3) agonist induces low-titre AMAs and in mild portal infiltrates. We took advantage of our established model to determine whether immunization with 2OA-BSA coupled with poly I:C alters the disease process. Indeed, the addition of poly I:C produces a profound exacerbation of autoimmune cholangitis, including a significant increase in CD8(+) infiltrating T cells, as well as a marked increase of proinflammatory cytokines. In addition, mice have evidence of fibrosis. These findings lend support to the concept that besides breakdown of self-tolerance, there is a requirement of a second 'hit' during the breakdown process that leads to disease which more faithfully mimics human PBC.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autoantibodies (日) (読) [継承]
3. (英) Autoantigens (日) (読) [継承]
4. (英) Autoimmune Diseases (日) (読) [継承]
5. (英) Cattle (日) (読) [継承]
6. (英) Cholangitis (日) (読) [継承]
7. (英) Cytokines (日) (読) [継承]
8. (英) Dihydrolipoyllysine-Residue Acetyltransferase (日) (読) [継承]
9. (英) Disease Models, Animal (日) (読) [継承]
10. (英) Fatty Acids, Monounsaturated (日) (読) [継承]
11. (英) Female (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13. (英) Immunization (日) (読) [継承]
14. (英) Liver (日) (読) [継承]
15. (英) Liver Cirrhosis, Biliary (日) (読) [継承]
16. (英) Male (日) (読) [継承]
17. (英) Mice (日) (読) [継承]
18. (英) Mice, Inbred C57BL (日) (読) [継承]
19. (英) Mitochondria (日) (読) [継承]
20. (英) Mitochondrial Proteins (日) (読) [継承]
21. (英) Poly I-C (日) (読) [継承]
22. (英) Serum Albumin (日) (読) [継承]
23. (英) Toll-Like Receptor 3 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 1365-2249
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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都市 (任意):
年月日 (必須): 西暦 2011年 10月 初日 (平成 23年 10月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2249.2011.04453.x    (→Scopusで検索) [継承]
PMID (任意): 21910728    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● M Y Ambrosini, G-X Yang, W Zhang, M Tsuda, S Shu, Koichi Tsuneyama, C P S Leung, A A Ansari, L R Coppel and E M Gershwin : The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis., Clinical and Experimental Immunology, Vol.166, No.1, 110-120, 2011.
欧文冊子 ● M Y Ambrosini, G-X Yang, W Zhang, M Tsuda, S Shu, Koichi Tsuneyama, C P S Leung, A A Ansari, L R Coppel and E M Gershwin : The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis., Clinical and Experimental Immunology, Vol.166, No.1, 110-120, 2011.

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