『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=371925EID:371925, Map:0, LastModified:2020年10月27日(火) 13:17:48, Operator:[松久 宗英], Avail:TRUE, Censor:0, Owner:[松久 宗英], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Watanabe Toshihiro (日) (読)
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2. (英) Fujimoto Yuki (日) (読)
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3. (英) Morimoto Aya (日) (読)
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4. (英) Nishiyama Mai (日) (読)
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5. (英) Kawai Akinori (日) (読)
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6. (英) Okada Seiki (日) (読)
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7. (英) Aiba Motohiro (日) (読)
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8. (英) Kawano Tomoharu (日) (読)
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9. (英) Kawahigashi Mina (日) (読)
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10. (英) Ishizu Masashi (日) (読)
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11.森 博康 ([徳島大学.先端酵素学研究所.基幹研究部門])
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12.松久 宗英 ([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任))
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13.秦 明子 ([徳島大学.病院.中央診療施設等.糖尿病対策センター])
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14.船木 真理 ([徳島大学.病院.中央診療施設等.糖尿病対策センター])
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15.橋田 誠一 ([宮崎医科大学])
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題名 (必須): (英) Development of fully automated and ultrasensitive assays for urinary adiponectin and their application as novel biomarkers for diabetic kidney disease.  (日)    [継承]
副題 (任意):
要約 (任意): (英)   (日) Glomerular filtration rate (GFR) and urinary albumin excretion rate (UAER) are used to diagnose and classify the severity of chronic kidney disease. Total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) assays were developed using the fully automated immunoassay system, HI-1000 and their significance over conventional biomarkers were investigated. The T-AN and H-AN assays had high reproducibility, good linearity, and sufficient sensitivity to detect trace amounts of adiponectin in the urine. Urine samples after gel filtration were analyzed for the presence of different molecular isoforms. Low molecular weight (LMW) forms and monomers were the major components (93%) of adiponectin in the urine from a diabetic patient with normoalbuminuria. Urine from a microalbuminuria patient contained both high molecular weight (HMW) (11%) and middle molecular weight (MMW) (28%) adiponectin, although the LMW level was still high (52%). The amount of HMW (32%) and MMW (42%) were more abundant than that of LMW (24%) in a diabetic patient with macroalbuminuria. T-AN (r = - 0.43) and H-AN (r = - 0.38) levels showed higher correlation with estimated GFR (eGFR) than UAER (r = - 0.23). Urinary levels of both T-AN and H-AN negatively correlated with renal function in diabetic patients and they may serve as new biomarkers for diabetic kidney disease.   [継承]
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誌名 (必須): Scientific Reports ([Nature Publishing Group])
(eISSN: 2045-2322)

ISSN (任意): 2045-2322
ISSN: 2045-2322 (eISSN: 2045-2322)
Title: Scientific reports
Title(ISO): Sci Rep
Publisher: Nature Publishing Group
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 10 [継承]
(必須): 1 [継承]
(必須): 15869 15869 [継承]
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年月日 (必須): 西暦 2020年 9月 28日 (令和 2年 9月 28日) [継承]
URL (任意):
DOI (任意): 10.1038/s41598-020-72494-6    (→Scopusで検索) [継承]
PMID (任意): 32985540    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Toshihiro Watanabe, Yuki Fujimoto, Aya Morimoto, Mai Nishiyama, Akinori Kawai, Seiki Okada, Motohiro Aiba, Tomoharu Kawano, Mina Kawahigashi, Masashi Ishizu, Hiroyasu Mori, Munehide Matsuhisa, Akiko Hata, Makoto Funaki and Seiichi Hashida : Development of fully automated and ultrasensitive assays for urinary adiponectin and their application as novel biomarkers for diabetic kidney disease., Scientific Reports, Vol.10, No.1, 15869, 2020.
欧文冊子 ● Toshihiro Watanabe, Yuki Fujimoto, Aya Morimoto, Mai Nishiyama, Akinori Kawai, Seiki Okada, Motohiro Aiba, Tomoharu Kawano, Mina Kawahigashi, Masashi Ishizu, Hiroyasu Mori, Munehide Matsuhisa, Akiko Hata, Makoto Funaki and Seiichi Hashida : Development of fully automated and ultrasensitive assays for urinary adiponectin and their application as novel biomarkers for diabetic kidney disease., Scientific Reports, Vol.10, No.1, 15869, 2020.

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