『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=370998EID:370998, Map:0, LastModified:2020年9月2日(水) 18:56:18, Operator:[橋本 登], Avail:TRUE, Censor:0, Owner:[橋本 登], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hamamura Kazunori (日) (読)
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[継承]
2. (英) Tsuji Momoko (日) (読)
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[継承]
3. (英) Hotta Hiroshi (日) (読)
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[継承]
4. (英) Ohkawa Yuki (日) (読)
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[継承]
5. (英) Takahashi Masataka (日) (読)
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6. (英) Shibuya Hidenobu (日) (読)
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7. (英) Nakashima Hideyuki (日) (読)
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8. (英) Yamauchi Yoshio (日) (読)
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9.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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[継承]
10. (英) Hattori Hisashi (日) (読)
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11. (英) Ueda Minoru (日) (読)
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12. (英) Furukawa Keiko (日) (読)
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13. (英) Furukawa Koichi (日) (読)
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題名 (必須): (英) Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The possible roles of Src family kinases in the enhanced malignant properties of melanomas related to GD3 expression were analyzed. Among Src family kinases only Yes, not Fyn or Src, was functionally involved in the increased cell proliferation and invasion of GD3-expressing transfectant cells (GD3+). Yes was located upstream of p130Cas and paxillin and at an equivalent level to focal adhesion kinase. Yes underwent autophosphorylation even before serum treatment and showed stronger kinase activity in GD3+ cells than in GD3- cells following serum treatment. Coimmunoprecipitation experiments revealed that Yes bound to focal adhesion kinase or p130Cas more strongly in GD3+ cells than in GD3- cells. As a possible mechanism for the enhancing effects of GD3 on cellular phenotypes, it was shown that majority of Yes was localized in glycolipid-enriched microdomain/rafts in GD3+ cells even before serum treatment, whereas it was scarcely detected in glycolipid-enriched microdomain/rafts in GD3- cells. An in vitro kinase assay of Yes revealed that coexistence of GD3 with Yes in membranous environments enhances the kinase activity of GD3- cell-derived Yes toward enolase, p125, and Yes itself. Knockdown of GD3 synthase resulted in the alleviation of tumor phenotypes and reduced activation levels of Yes. Taken together, these results suggest a role of GD3 in the regulation of Src family kinases.  (日)    [継承]
キーワード (推奨): 1. (英) Cell Line, Tumor (日) (読) [継承]
2. (英) Crk-Associated Substrate Protein (日) (読) [継承]
3. (英) Enzyme Activation (日) (読) [継承]
4. (英) Focal Adhesion Protein-Tyrosine Kinases (日) (読) [継承]
5. (英) Gangliosides (日) (読) [継承]
6. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
7. (英) Gene Knockdown Techniques (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Melanoma (日) (読) [継承]
10. (英) Membrane Microdomains (日) (読) [継承]
11. (英) Phosphopyruvate Hydratase (日) (読) [継承]
12. (英) Proto-Oncogene Proteins c-yes (日) (読) [継承]
13. (英) Sialyltransferases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 286 [継承]
(必須): 21 [継承]
(必須): 18526 18537 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 3月 31日 (平成 23年 3月 31日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M110.164798    (→Scopusで検索) [継承]
PMID (任意): 21454696    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazunori Hamamura, Momoko Tsuji, Hiroshi Hotta, Yuki Ohkawa, Masataka Takahashi, Hidenobu Shibuya, Hideyuki Nakashima, Yoshio Yamauchi, Noboru Hashimoto, Hisashi Hattori, Minoru Ueda, Keiko Furukawa and Koichi Furukawa : Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3., The Journal of Biological Chemistry, Vol.286, No.21, 18526-18537, 2011.
欧文冊子 ● Kazunori Hamamura, Momoko Tsuji, Hiroshi Hotta, Yuki Ohkawa, Masataka Takahashi, Hidenobu Shibuya, Hideyuki Nakashima, Yoshio Yamauchi, Noboru Hashimoto, Hisashi Hattori, Minoru Ueda, Keiko Furukawa and Koichi Furukawa : Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3., The Journal of Biological Chemistry, Vol.286, No.21, 18526-18537, 2011.

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