『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hotta Hiroshi (日) (読)
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[継承]
2. (英) Hamamura Kazunori (日) (読)
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[継承]
3. (英) Yamashita Kyoko (日) (読)
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[継承]
4. (英) Shibuya Hidenobu (日) (読)
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[継承]
5. (英) Tokuda Noriyo (日) (読)
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[継承]
6.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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[継承]
7. (英) Furukawa Keiko (日) (読)
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[継承]
8. (英) Yamamoto Noriyuki (日) (読)
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[継承]
9. (英) Hattori Hisashi (日) (読)
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[継承]
10. (英) Toyokuni Shinya (日) (読)
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[継承]
11. (英) Ueda Minoru (日) (読)
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[継承]
12. (英) Furukawa Koichi (日) (読)
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[継承]
題名 (必須): (英) Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.  (日)    [継承]
副題 (任意):
要約 (任意): (英)   (日) Expression and implication of carbohydrate antigens in squamous cell carcinomas (SCCs) in oral cavity was examined. In the cell lines, type 2H and Lewis y antigens were markedly expressed. In the tissues from SCC patients and benign disorders, type 2H was highly expressed in hyperplasia (96.4 %), displasia (92.9 %) and SCC (100 %). Lewis y was, in turn, expressed mainly in cancer tissues (91.3 %), suggesting that Lewis y is a cancer-associated antigen. Normal oral mucosa showed no expression of these blood group antigens. Surprisingly, Lewis y antigen disappeared in the invasion sites where Ki-67 was definitely stained. Over-expression of Lewis y with manipulation of a fucosyltransferase cDNA resulted in suppression of cell growth and invasion, and knockdown of Lewis y also brought about increased cell growth and invasion. In either situations, no changes in the expression of sialyl-Lewis x could be found. Lowered tumor growth and invasion into surrounding tissues were also shown in Lewis y-positive SCC grafts in nu/nu mice. All these results together with alternative staining between Lewis y and Ki-67 in cancer tissues and FUT1 transfectants suggested that loss of Lewis y is a crucial event for the late stage of SCCs.   [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Carcinoma, Squamous Cell (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Fucosyltransferases (日) (読) [継承]
5. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Ki-67 Antigen (日) (読) [継承]
8. (英) Lewis Blood Group Antigens (日) (読) [継承]
9. (英) Mice, Inbred BALB C (日) (読) [継承]
10. (英) Mouth Mucosa (日) (読) [継承]
11. (英) Mouth Neoplasms (日) (読) [継承]
12. (英) Neoplasm Invasiveness (日) (読) [継承]
13. (英) Neoplasm Transplantation (日) (読) [継承]
14. (英) Oligosaccharides (日) (読) [継承]
15. (英) Organ Specificity (日) (読) [継承]
16. (英) Sialyl Lewis X Antigen (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Glycoconjugate Journal (International Glycoconjugate Organization)
(pISSN: 0282-0080, eISSN: 1573-4986)

ISSN (任意): 1573-4986
ISSN: 0282-0080 (pISSN: 0282-0080, eISSN: 1573-4986)
Title: Glycoconjugate journal
Title(ISO): Glycoconj J
Supplier: Kluwer Online
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 30 [継承]
(必須): 6 [継承]
(必須): 585 597 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 12月 15日 (平成 24年 12月 15日) [継承]
URL (任意):
DOI (任意): 10.1007/s10719-012-9458-2    (→Scopusで検索) [継承]
PMID (任意): 23242548    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hiroshi Hotta, Kazunori Hamamura, Kyoko Yamashita, Hidenobu Shibuya, Noriyo Tokuda, Noboru Hashimoto, Keiko Furukawa, Noriyuki Yamamoto, Hisashi Hattori, Shinya Toyokuni, Minoru Ueda and Koichi Furukawa : Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x., Glycoconjugate Journal, Vol.30, No.6, 585-597, 2012.
欧文冊子 ● Hiroshi Hotta, Kazunori Hamamura, Kyoko Yamashita, Hidenobu Shibuya, Noriyo Tokuda, Noboru Hashimoto, Keiko Furukawa, Noriyuki Yamamoto, Hisashi Hattori, Shinya Toyokuni, Minoru Ueda and Koichi Furukawa : Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x., Glycoconjugate Journal, Vol.30, No.6, 585-597, 2012.

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