『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=370993)

EID=370993EID:370993, Map:0, LastModified:2020年9月2日(水) 18:51:39, Operator:[橋本 登], Avail:TRUE, Censor:0, Owner:[橋本 登], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tokuda Noriyo (日) (読)
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[継承]
2. (英) Numata Shinichiro (日) (読)
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[継承]
3. (英) Li Xiaojin (日) (読)
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[継承]
4. (英) Nomura Tomoko (日) (読)
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[継承]
5. (英) Takizawa Minoru (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Kondo Yuji (日) (読)
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[継承]
7. (英) Yamashita Yoriko (日) (読)
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[継承]
8.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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学籍番号 (推奨):
[継承]
9. (英) Kiyono Tohru (日) (読)
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[継承]
10. (英) Urano Takeshi (日) (読)
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[継承]
11. (英) Furukawa Keiko (日) (読)
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学籍番号 (推奨):
[継承]
12. (英) Furukawa Koichi (日) (読)
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[継承]
題名 (必須): (英) β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Glycosphingolipids are expressed on the cell membrane and act as important factors in various events that occur across the plasma membrane. Lactosylceramide (LacCer) is synthesized from glucosylceramide and is a common precursor of various glycosphingolipids existing in whole body. Based on the enzyme purification, β1,4-galactosyltransferase 6 (B4galt6) cDNA was isolated as a LacCer synthase-coding gene in the rat brain. We generated B4galt6 gene knockout (KO) mice and analyzed their phenotypes to examine roles of β4GalT6. B4galt6 KO mice were born and grew up apparently normal. LacCer synthase activity and the composition of acidic glycosphingolipids in the brain were almost equivalent or minimally different between wild-type and KO mice. Studies by mouse embryonic fibroblasts (MEFs) revealed that the silencing of B4galt5 gene resulted in the marked reduction in LacCer synthase activity and this reduction was more severe in MEFs derived from B4galt6 KO mice than those from wild-type mice. These results suggested that β4GalT6 plays a role as a LacCer synthase, whereas β4GalT5 acts as a main enzyme for LacCer biosynthesis in these tissues and cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Brain (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) Galactosyltransferases (日) (読) [継承]
5. (英) Lactosylceramides (日) (読) [継承]
6. (英) Mice (日) (読) [継承]
7. (英) Mice, Inbred C57BL (日) (読) [継承]
8. (英) Mice, Knockout (日) (読) [継承]
9. (英) Phenotype (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Glycobiology (Society for Glycobiology)
(pISSN: 0959-6658, eISSN: 1460-2423)

ISSN (任意): 1460-2423
ISSN: 0959-6658 (pISSN: 0959-6658, eISSN: 1460-2423)
Title: Glycobiology
Title(ISO): Glycobiology
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 23 [継承]
(必須): 10 [継承]
(必須): 1175 1183 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 7月 23日 (平成 25年 7月 23日) [継承]
URL (任意):
DOI (任意): 10.1093/glycob/cwt054    (→Scopusで検索) [継承]
PMID (任意): 23882130    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Noriyo Tokuda, Shinichiro Numata, Xiaojin Li, Tomoko Nomura, Minoru Takizawa, Yuji Kondo, Yoriko Yamashita, Noboru Hashimoto, Tohru Kiyono, Takeshi Urano, Keiko Furukawa and Koichi Furukawa : β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5., Glycobiology, Vol.23, No.10, 1175-1183, 2013.
欧文冊子 ● Noriyo Tokuda, Shinichiro Numata, Xiaojin Li, Tomoko Nomura, Minoru Takizawa, Yuji Kondo, Yoriko Yamashita, Noboru Hashimoto, Tohru Kiyono, Takeshi Urano, Keiko Furukawa and Koichi Furukawa : β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5., Glycobiology, Vol.23, No.10, 1175-1183, 2013.

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