『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=370991)

EID=370991EID:370991, Map:0, LastModified:2020年9月2日(水) 18:50:16, Operator:[橋本 登], Avail:TRUE, Censor:0, Owner:[橋本 登], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Sabit Ilhamjan (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Matsumoto Yasuyuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Yamaji Toshiyuki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Furukawa Keiko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Furukawa Koichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Although regulatory mechanisms for immune cells with inhibitory signals via immunoreceptor tyrosine-based inhibitory motifs are well known, signals transduced via interaction between Siglecs and sialyl compounds on their counterreceptors into target cells have not been reported to date. In this study, we found that an astrocytoma cell line, AS, showed detachment from culture plates when co-cultured with Siglec-9-expressing cells and/or soluble Siglec-9. Moreover, detached AS cells regrew as co-cultured cells with Siglec-9-deficient cells. They also showed increased motility and invasiveness upon Siglec-9 binding. In immunoblotting, rapid degradation of focal adhesion kinase (FAK) and related signaling molecules such as Akt, paxillin, and p130Cas was observed immediately after the co-culture. Despite degradation of these molecules, increased p-Akt was found at the front region of the cytoplasm, probably reflecting increased cell motility. Calpain was considered to be a responsible protease for the protein degradation by the inhibition experiments. These results suggest that protein degradation of FAK and related molecules was induced by Siglec-9 binding to its counterreceptors via sialylglycoconjugates, leading to the modulation of adhesion kinetics of cancer cells. Thus, this might be a mechanism by which cancer cells utilize Siglec-9-derived signals to escape from immunosurveillance.  (日)    [継承]
キーワード (推奨): 1. (英) Antigens, CD (日) (読) [継承]
2. (英) Calpain (日) (読) [継承]
3. (英) Cell Adhesion (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Focal Adhesion Kinase 1 (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Neoplasm Proteins (日) (読) [継承]
8. (英) Neoplasms (日) (読) [継承]
9. (英) Protein Binding (日) (読) [継承]
10. (英) Receptors, Mitogen (日) (読) [継承]
11. (英) Sialic Acid Binding Immunoglobulin-like Lectins (日) (読) [継承]
12.シグナル伝達 (signal transduction) [継承]
13. (英) U937 Cells (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 288 [継承]
(必須): 49 [継承]
(必須): 35417 35427 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 10月 21日 (平成 25年 10月 21日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M113.513192    (→Scopusで検索) [継承]
PMID (任意): 24145038    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ilhamjan Sabit, Noboru Hashimoto, Yasuyuki Matsumoto, Toshiyuki Yamaji, Keiko Furukawa and Koichi Furukawa : Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation., The Journal of Biological Chemistry, Vol.288, No.49, 35417-35427, 2013.
欧文冊子 ● Ilhamjan Sabit, Noboru Hashimoto, Yasuyuki Matsumoto, Toshiyuki Yamaji, Keiko Furukawa and Koichi Furukawa : Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation., The Journal of Biological Chemistry, Vol.288, No.49, 35417-35427, 2013.

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