『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ando Reiko (日) (読)
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[継承]
2. (英) Tokuda Noriyo (日) (読)
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[継承]
3. (英) Yamamoto Tokunori (日) (読)
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[継承]
4. (英) Ikeda Kazutaka (日) (読)
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[継承]
5.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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[継承]
6. (英) Taguchi Ryo (日) (読)
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[継承]
7. (英) Fan Xiaoen (日) (読)
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[継承]
8. (英) Furukawa Keiko (日) (読)
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[継承]
9. (英) Niimura Yukio (日) (読)
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[継承]
10. (英) Suzuki Akemi (日) (読)
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[継承]
11. (英) Goto Momokazu (日) (読)
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[継承]
12. (英) Furukawa Koichi (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies.  (日)    [継承]
副題 (任意):
要約 (任意): (英) In this study, we immunized Gb3/CD77 synthase gene (A4galt) knockout (KO) mice with glycosphingolipids (GSLs) extracted from 3 renal cell cancer (RCC) cell lines to raise monoclonal antibodies (mAbs) reactive with globo-series GSLs specifically expressed in RCCs. Although a number of mAbs reactive with globo-series GSLs were generated, they reacted with both RCC cell lines and normal kidney cells. When we analyzed recognized antigens by mAbs that were specifically reactive with RCC, but not with normal kidney cells at least on the cell surface, many of them turned out to be reactive with sulfoglycolipids. Eight out of 11 RCC-specific mAbs were reactive with SM2 alone, and the other 3 mAbs were more broadly reactive with sulfated glycolipids, i.e. SM3 and SM4 as well as SM2. In the immunohistochemistry, these anti-sulfoglycolipids mAbs showed RCC-specific reaction, with no or minimal reaction with adjacent normal tissues. Thus, immunization of A4galt KO mice with RCC-derived GSLs resulted in the generation of anti sulfated GSL mAbs, and these mAbs may be applicable for the therapeutics for RCC patients.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies, Monoclonal, Murine-Derived (日) (読) [継承]
3. (英) Antibodies, Neoplasm (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Galactosyltransferases (日) (読) [継承]
6. (英) Glycolipids (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Immunization (日) (読) [継承]
9. (英) Kidney Neoplasms (日) (読) [継承]
10.ノックアウトマウス (knockout mice) [継承]
発行所 (推奨):
誌名 (必須): Glycoconjugate Journal (International Glycoconjugate Organization)
(pISSN: 0282-0080, eISSN: 1573-4986)

ISSN (任意): 1573-4986
ISSN: 0282-0080 (pISSN: 0282-0080, eISSN: 1573-4986)
Title: Glycoconjugate journal
Title(ISO): Glycoconj J
Supplier: Kluwer Online
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2016年 2月 16日 (平成 28年 2月 16日) [継承]
URL (任意):
DOI (任意): 10.1007/s10719-016-9654-6    (→Scopusで検索) [継承]
PMID (任意): 26883028    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Reiko Ando, Noriyo Tokuda, Tokunori Yamamoto, Kazutaka Ikeda, Noboru Hashimoto, Ryo Taguchi, Xiaoen Fan, Keiko Furukawa, Yukio Niimura, Akemi Suzuki, Momokazu Goto and Koichi Furukawa : Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies., Glycoconjugate Journal, Vol.33, No.2, 169-180, 2016.
欧文冊子 ● Reiko Ando, Noriyo Tokuda, Tokunori Yamamoto, Kazutaka Ikeda, Noboru Hashimoto, Ryo Taguchi, Xiaoen Fan, Keiko Furukawa, Yukio Niimura, Akemi Suzuki, Momokazu Goto and Koichi Furukawa : Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies., Glycoconjugate Journal, Vol.33, No.2, 169-180, 2016.

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