『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=370983)

EID=370983EID:370983, Map:0, LastModified:2020年9月2日(水) 18:40:28, Operator:[橋本 登], Avail:TRUE, Censor:0, Owner:[橋本 登], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ohkawa Yuki (日) (読)
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[継承]
2. (英) Momota Hiroyuki (日) (読)
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[継承]
3. (英) Kato Akira (日) (読)
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[継承]
4.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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学籍番号 (推奨):
[継承]
5. (英) Tsuda Yusuke (日) (読)
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[継承]
6. (英) Kotani Norihiro (日) (読)
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[継承]
7. (英) Honke Koichi (日) (読)
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[継承]
8. (英) Suzumura Akio (日) (読)
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[継承]
9. (英) Furukawa Keiko (日) (読)
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[継承]
10. (英) Ohmi Yuhsuke (日) (読)
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[継承]
11. (英) Natsume Atsushi (日) (読)
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12. (英) Wakabayashi Toshihiko (日) (読)
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[継承]
13. (英) Furukawa Koichi (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase.  (日)    [継承]
副題 (任意):
要約 (任意): (英) There have been a few studies on the ganglioside expression in human glioma tissues. However, the role of these gangliosides such as GD3 and GD2 has not been well understood. In this study we employed a genetically engineered mouse model of glioma to clarify the functions of GD3 in gliomas. Forced expression of platelet-derived growth factor B in cultured astrocytes derived from p53-deficient mice resulted in the expression of GD3 and GD2. GD3-positive astrocytes exhibited increased cell growth and invasion activities along with elevated phosphorylation of Akt and Yes kinase. By enzyme-mediated activation of radical sources reaction and mass spectrometry, we identified PDGF receptor α (PDGFRα) as a GD3-associated molecule. GD3-positive astrocytes showed a significant amount of PDGFRα in glycolipid-enriched microdomains/rafts compared with GD3-negative cells. Src kinase family Yes was co-precipitated with PDGFRα, and its pivotal role in the increased cell invasion of GD3-positive astrocytes was demonstrated by silencing with anti-Yes siRNA. Direct association between PDGFRα and GD3 was also shown, suggesting that GD3 forms ternary complex with PDGFRα and Yes. The fact that GD3, PDGFRα, and activated Yes were colocalized in lamellipodia and the edge of tumors in cultured cells and glioma tissues, respectively, suggests that GD3 induced by platelet-derived growth factor B enhances PDGF signals in glycolipid-enriched microdomain/rafts, leading to the promotion of malignant phenotypes such as cell proliferation and invasion in gliomas.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Brain Neoplasms (日) (読) [継承]
3. (英) Gangliosides (日) (読) [継承]
4. (英) Glioma (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Mice (日) (読) [継承]
7. (英) Neoplasm Invasiveness (日) (読) [継承]
8. (英) Protein Binding (日) (読) [継承]
9. (英) Proto-Oncogene Proteins c-yes (日) (読) [継承]
10. (英) Receptor, Platelet-Derived Growth Factor alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 290 [継承]
(必須): 26 [継承]
(必須): 16043 16058 [継承]
都市 (任意):
年月日 (必須): 西暦 2015年 5月 4日 (平成 27年 5月 4日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M114.635755    (→Scopusで検索) [継承]
PMID (任意): 25940087    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yuki Ohkawa, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yusuke Tsuda, Norihiro Kotani, Koichi Honke, Akio Suzumura, Keiko Furukawa, Yuhsuke Ohmi, Atsushi Natsume, Toshihiko Wakabayashi and Koichi Furukawa : Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase., The Journal of Biological Chemistry, Vol.290, No.26, 16043-16058, 2015.
欧文冊子 ● Yuki Ohkawa, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yusuke Tsuda, Norihiro Kotani, Koichi Honke, Akio Suzumura, Keiko Furukawa, Yuhsuke Ohmi, Atsushi Natsume, Toshihiko Wakabayashi and Koichi Furukawa : Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase., The Journal of Biological Chemistry, Vol.290, No.26, 16043-16058, 2015.

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