『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=370966EID:370966, Map:0, LastModified:2020年9月2日(水) 19:45:29, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[高山 哲治], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨):
著者 (必須): 1.曽我部 正弘 ([徳島大学.キャンパスライフ健康支援センター])
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2.岡久 稔也 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域総合医療学]/[徳島大学.病院.診療科.内科.消化器内科])
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3. (英) Kurihara Takeshi (日) 栗原 健士 (読) くりはら たけし
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学籍番号 (推奨): **** [ユーザ]
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4.武原 正典
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5. (英) Kagemoto Kaizoh (日) 影本 開三 (読) かげもと かいぞう
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学籍番号 (推奨): **** [ユーザ]
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6.岡崎 潤
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7.喜田 慶史
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8. (英) Hirao Akihiro (日) 平尾 章博 (読) ひらお あきひろ
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9.田中 宏典 ([徳島大学.病院.中央診療施設等.安全管理部])
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学籍番号 (推奨): **** [ユーザ]
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10.友成 哲 ([徳島大学.病院.診療科.内科.消化器内科])
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学籍番号 (推奨): **** [ユーザ]
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11.谷口 達哉 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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学籍番号 (推奨): **** [ユーザ]
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12.岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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13. (英) Nakasono Masahiro (日) (読)
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14.高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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題名 (必須): (英) Differences among patients with and without nonalcoholic fatty liver disease having elevated alanine aminotransferase levels at various stages of metabolic syndrome.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The prevalence of nonalcoholic fatty liver disease (NAFLD) in the non-obese population has increased and NAFLD is not always recognized in individuals with metabolic syndrome (MS). The risk of cirrhosis is higher in patients having NAFLD with elevated alanine aminotransferase (ALT) levels than in those having NAFLD with normal ALT levels. To measure the differences in clinical factors associated with NAFLD having elevation of ALT among subjects with Non-MS, Pre-MS, and MS, and to measure differences in metabolites between MS subjects with and without NAFLD having elevation of ALT. Among 7,054 persons undergoing health check-ups, we included 3,025 subjects who met the selection criteria. We measured differences in clinical factors for NAFLD having elevation of ALT among subjects with Non-MS, Pre-MS, and MS, and compared metabolites between subjects with and without NAFLD having elevation of ALT in 32 subjects with MS. The prevalence of NAFLD and NAFLD having elevation of ALT was significantly progressively greater in subjects with Non-MS, Pre-MS, and MS (p <0.001, respectively). In the Non-MS group, there were significant differences between subjects with and without NAFLD having elevation of ALT with respect to body mass index (BMI), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, hemoglobin A1c, uric acid, aspartate aminotransferase (AST); In the Pre-MS group, there were significant differences in BMI, hypertension, AST, and gamma-glutamyl transpeptidase (GGT); In the MS group, there were significant differences in HDL-C, impaired glucose tolerance, AST, and GGT. There were significant differences in levels of metabolites of nicotinamide, inosine, and acetyl-L-carnitine between MS subjects with and without NAFLD having elevation of ALT (all p <0.05). Although NAFLD having elevation of ALT is important for development of NAFLD, differences in factors associated with NAFLD having elevation of ALT at various stages of MS should be considered. Additionally, several metabolites may play roles in the identification of risk for NAFLD in individuals with MS.  (日)    [継承]
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誌名 (必須): PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)

ISSN (任意): 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 15 [継承]
(必須): 8 [継承]
(必須): e0238388 e0238388 [継承]
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年月日 (必須): 西暦 2020年 8月 31日 (令和 2年 8月 31日) [継承]
URL (任意):
DOI (任意): 10.1371/journal.pone.0238388    (→Scopusで検索) [継承]
PMID (任意): 32866186    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1371/journal.pone.0238388  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) CoiStatement: The authors have declared that no competing interests exist.  (日)    [継承]

標準的な表示

和文冊子 ● Masahiro Sogabe, Toshiya Okahisa, Takeshi Kurihara, Masanori Takehara, Kaizoh Kagemoto, Jun Okazaki, Yoshifumi Kida, Akihiro Hirao, Hironori Tanaka, Tetsu Tomonari, Tatsuya Taniguchi, Koichi Okamoto, Masahiro Nakasono and Tetsuji Takayama : Differences among patients with and without nonalcoholic fatty liver disease having elevated alanine aminotransferase levels at various stages of metabolic syndrome., PLoS ONE, Vol.15, No.8, e0238388, 2020.
欧文冊子 ● Masahiro Sogabe, Toshiya Okahisa, Takeshi Kurihara, Masanori Takehara, Kaizoh Kagemoto, Jun Okazaki, Yoshifumi Kida, Akihiro Hirao, Hironori Tanaka, Tetsu Tomonari, Tatsuya Taniguchi, Koichi Okamoto, Masahiro Nakasono and Tetsuji Takayama : Differences among patients with and without nonalcoholic fatty liver disease having elevated alanine aminotransferase levels at various stages of metabolic syndrome., PLoS ONE, Vol.15, No.8, e0238388, 2020.

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