『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Wang Xiaoke (日) (読)
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2. (英) Zhu Piaoyu (日) (読)
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3. (英) Xu Shenya (日) (読)
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4. (英) Liu Yuting (日) (読)
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5. (英) Jin Yang (日) (読)
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6. (英) Yu Shali (日) (読)
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7. (英) Wei Haiyan (日) (読)
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8. (英) Li Jinlong (日) (読)
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9. (英) Zhang Qinglin (日) (読)
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10.長谷川 敬展 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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11.姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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12.吉村 弘 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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13. (英) Wu Qiyun (日) (読)
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14. (英) Zhao Xinyuan (日) (読)
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○題名 (必須): □(英) Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Antimony (Sb), a naturally occurring metal present in air and drinking water, has been found in the human brain, and there is evidence of its toxic effects on neurobehavioral perturbations, suggesting that Sb is a potential nerve poison. Here, we provide the first study on the molecular mechanism underlying Sb-associated neurotoxicity. Mice exposed to antimony potassium tartrate hydrate showed significantly increased neuronal apoptosis. In vitro, Sb triggered apoptosis in PC12 cells in a dose-dependent manner. Mechanically, Sb triggered autophagy as indicated by increased expression of microtubule-associated protein 1 light chain 3-II (LC3-II) and accumulation of green fluorescent protein-tagged LC3 dots. Moreover, Sb enhanced autophagic flux and sequestosome 1 (p62) degradation. Subsequent analyses showed that Sb treatment decreased phosphorylation of protein kinase B (Akt) as well as the mammalian target of rapamycin (mTOR), while an Akt activator protected PC12 cells from autophagy. Moreover, the antioxidant N-acetylcysteine attenuated Sb-induced Akt/mTOR inhibition and decreased autophagy and apoptosis, with autophagy inhibition also playing a cytoprotective role. In vivo, mice treated with Sb showed higher expression of LC3-II and p62 in the brain, consistent with the in vitro results. In summary, Sb induced autophagic cell death through reactive oxygen species-mediated inhibition of the Akt/mTOR pathway.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antimony (日) (読) [継承]
3. (英) Autophagic Cell Death (日) (読) [継承]
4. (英) Mice (日) (読) [継承]
5. (英) Nerve Agents (日) (読) [継承]
6. (英) Neurons (日) (読) [継承]
7. (英) PC12 Cells (日) (読) [継承]
8. (英) Proto-Oncogene Proteins c-akt (日) (読) [継承]
9. (英) Rats (日) (読) [継承]
10. (英) Reactive Oxygen Species (日) (読) [継承]
11. (英) TOR Serine-Threonine Kinases (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □The International Journal of Biochemistry & Cell Biology ([Elsevier])
(pISSN: 1357-2725, eISSN: 1878-5875)

○ISSN (任意): □1878-5875
ISSN: 1357-2725 (pISSN: 1357-2725, eISSN: 1878-5875)
Title: The international journal of biochemistry & cell biology
Title(ISO): Int J Biochem Cell Biol
Publisher: Elsevier Ltd.
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □114 [継承]
○号 (必須):
○頁 (必須): □105561 105561 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2019年 6月 20日 (令和 元年 6月 20日) [継承]
○URL (任意):
○DOI (任意): □10.1016/j.biocel.2019.105561    (→Scopusで検索) [継承]
○PMID (任意): □31228582    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) Article.ELocationID: S1357-2725(19)30132-3  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.biocel.2019.105561  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) KeywordList.Keyword: Akt/mTOR inhibition  (日)    [継承]
6.(英) KeywordList.Keyword: Antimony  (日)    [継承]
7.(英) KeywordList.Keyword: Autophagy  (日)    [継承]
8.(英) KeywordList.Keyword: Neuronal apoptosis  (日)    [継承]
9.(英) KeywordList.Keyword: Neurotoxicity  (日)    [継承]
10.(英) KeywordList.Keyword: ROS  (日)    [継承]

標準的な表示

和文冊子 ● Xiaoke Wang, Piaoyu Zhu, Shenya Xu, Yuting Liu, Yang Jin, Shali Yu, Haiyan Wei, Jinlong Li, Qinglin Zhang, Takahiro Hasegawa, Chenjuan Yao, Hiroshi Yoshimura, Qiyun Wu and Xinyuan Zhao : Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway., The International Journal of Biochemistry & Cell Biology, Vol.114, (号), 105561, 2019.
欧文冊子 ● Xiaoke Wang, Piaoyu Zhu, Shenya Xu, Yuting Liu, Yang Jin, Shali Yu, Haiyan Wei, Jinlong Li, Qinglin Zhang, Takahiro Hasegawa, Chenjuan Yao, Hiroshi Yoshimura, Qiyun Wu and Xinyuan Zhao : Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway., The International Journal of Biochemistry & Cell Biology, Vol.114, (号), 105561, 2019.

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