『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=369266)

EID=369266EID:369266, Map:0, LastModified:2021年8月24日(火) 16:52:27, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 著書 [継承]
言語 (必須): 英語 [継承]
招待 (推奨): 依頼 [継承]
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Abe Chiaki (日) 安部 千秋 (読) あべ ちあき
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
3. (英) Futawaka Mana (日) 二若 真菜 (読) ふたわか まな
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
4.山田 久嗣 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.富永 正英 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.医用画像解析学]/[徳島大学.医学部.保健学科.放射線技術科学専攻.診療放射線技術学講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Endo Yoshio (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) In vivo drug screening method of radiosensitizers using tumor-bearing chick embryo  (日)    [継承]
副題 (任意):
要約 (任意): (英) In radiotherapy, tumor hypoxia is the main factor responsible for treatment resistance, and the development of radiosensitizers that can overcome this is imperative. However, many drugs that are effective in vitro and in vivo fail in clinical trials, and thus it is necessary to develop an animal model that can be used for the correct evaluation of pharmacokinetics and activity. Developing chicken eggs are commonly used in various research fields such as anticancer drug sensitivity tests and cardiotoxicity tests. We examined whether the radiosensitizing activity of etanidazole, as a hypoxic cell radiosensitizer, could be evaluated using tumor-bearing chick embryo. Following the transplantation of mouse mammary carcinoma EMT6 cells on day 11, a solid tumor was formed on day 15 and an evaluation of the time-course of the tumor revealed that the tumor weight was the highest on day 18. The maximum dose of etanidazole that did not affect tumor growth and fetal survival was 1.0mg and the maximum X-ray dose was 8Gy. Etanidazole was intravenously administered 10min prior to single dose X-ray irradiation. A significant tumor growth inhibitory effect was confirmed with 1.0mg of etanidazole in combination with 8Gy X-ray. In the case of mouse colon cancer colon26 cells, the combination of 3.0mg of etanidazole and 2Gy X-ray showed 2.79 times higher radiosensitizing activity than that observed for the control group. These results demonstrate that it is possible to evaluate the activity of radiosensitizers using tumor-bearing chick embryo.  (日)    [継承]
キーワード (推奨): 1. (英) Etanidazole (日) (読) [継承]
2. (英) Hypoxic cell radiosensitizer (日) (読) [継承]
3. (英) Mouse colon cancer colon26 cell (日) (読) [継承]
4. (英) Mouse mammary carcinoma EMT6 cell (日) (読) [継承]
5. (英) Tumor-bearing chick embryo (日) (読) [継承]
発行所 (必須): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (任意): The Enzymes ([Elsevier])
(pISSN: 0423-2607, eISSN: 1874-6047)

ISSN (任意): 0423-2607
ISSN: 0423-2607 (pISSN: 0423-2607, eISSN: 1874-6047)
Title: The Enzymes
Title(ISO): Enzymes
Publisher: Elsevier BV
 (NLM Catalog  (Scopus (Scopus information is found. [need login])
[継承]
[継承]
(任意): 46 [継承]
(任意): [継承]
(任意): 113 127 [継承]
都市 (必須):
年月日 (必須): 西暦 2019年 10月 18日 (令和 元年 10月 18日) [継承]
URL (任意):
DOI (任意): 10.1016/bs.enz.2019.08.008    (→Scopusで検索) [継承]
PMID (任意): 31727273    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨): 1.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座]) [継承]
備考 (任意): 1.(英) Article.ELocationID: S1874-6047(19)30014-9  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/bs.enz.2019.08.008  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: Etanidazole  (日)    [継承]
5.(英) KeywordList.Keyword: Hypoxic cell radiosensitizer  (日)    [継承]
6.(英) KeywordList.Keyword: Mouse colon cancer colon26 cell  (日)    [継承]
7.(英) KeywordList.Keyword: Mouse mammary carcinoma EMT6 cell  (日)    [継承]
8.(英) KeywordList.Keyword: Tumor-bearing chick embryo  (日)    [継承]

標準的な表示

和文冊子 ● Yoshihiro Uto, Chiaki Abe, Mana Futawaka, Hisatsugu Yamada, Masahide Tominaga and Yoshio Endo : In vivo drug screening method of radiosensitizers using tumor-bearing chick embryo, Elsevier, (都市), Oct. 2019.
欧文冊子 ● Yoshihiro Uto, Chiaki Abe, Mana Futawaka, Hisatsugu Yamada, Masahide Tominaga and Yoshio Endo : In vivo drug screening method of radiosensitizers using tumor-bearing chick embryo, Elsevier, (都市), Oct. 2019.

関連情報

Number of session users = 0, LA = 0.51, Max(EID) = 382712, Max(EOID) = 1022125.