| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 武原 正典
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 佐藤 康史 ([徳島大学.病院.診療科.内科.消化器内科])
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| 3. | 木村 哲夫
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| 4. | (英) (日) (読)
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 野田 和克
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 7. | 藤野 泰輝
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| 8. | 三好 人正
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| ○学籍番号 (推奨): | □ | ****
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| 9. | 中村 文香
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| ○学籍番号 (推奨): | □ | ****
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| 10. | (英) Wada Hironori (日) (読)
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| 11. | 坂東 良美 ([徳島大学.病院.診療科.病理診断科])
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| 12. | 池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 13. | 島田 光生
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| 14. | 六車 直樹
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| 15. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Cancer-associated Adipocytes Promote Pancreatic Cancer Progression Through SAA1 Expression (日)
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| ○要約 (任意): | □ | (英) Although pancreatic cancer often invades into peripancreatic adipose tissue, little is known about the cancer-adipocyte interaction. We first investigated the ability of adipocytes to de-differentiate to cancer-associated adipocytes (CAAs) by co-culturing with pancreatic cancer cells. We then examined the effects of CAA-conditioned media (CAA-CM) on the malignant characteristics of cancer cells, the mechanism underlying those effects, and their clinical relevance in pancreatic cancer. When 3T3-L1 adipocytes were co-cultured with pancreatic cancer cells (PANC-1) using Transwell system, adipocytes lost their lipid droplets and morphologically changed to fibroblast-like cells (CAA). Adipocyte-specific marker mRNA levels significantly decreased but those of fibroblast-specific markers appeared, characteristic findings of CAA, as revealed by real-time PCR. When PANC-1 cells were cultured with CAA-CM, significantly higher migration/invasion capability, chemoresistance, and epithelial-mesenchymal transition (EMT) properties were observed compared with control cells. To investigate the mechanism underlying these effects, we performed microarray analysis of PANC-1 cells cultured with CAA-CM, and found 78.5-fold higher expression of SAA1 compared with control cells. When SAA1 gene in PANC-1 cells was knocked down with SAA1 siRNA, migration/invasion capability, chemoresistance, and EMT properties were significantly attenuated compared with control cells. Immunohistochemical analysis on human pancreatic cancer tissues revealed positive SAA1 expression in 46/61 (75.4%). Overall survival in the SAA1-positive group was significantly shorter than in the SAA1-negative group (p=0.013). In conclusion, we demonstrated that pancreatic cancer cells induced de-differentiation in adipocytes toward CAA, and CAA promoted malignant characteristics of pancreatic cancer via SAA1 expression, suggesting that SAA1 is a novel therapeutic target in pancreatic cancer. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cancer Science ([日本癌学会])
(pISSN: 1347-9032, eISSN: 1349-7006)
| ○ISSN (任意): | □ | 1349-7006
ISSN: 1347-9032
(pISSN: 1347-9032, eISSN: 1349-7006) Title: Cancer scienceTitle(ISO): Cancer SciPublisher: Wiley-Blackwell (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 111
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| ○号 (必須): | □ | 8
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| ○頁 (必須): | □ | 2883 2894
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 7月 14日 (令和 2年 7月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/cas.14527 (→Scopusで検索)
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| ○PMID (任意): | □ | 32535957 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85087562532
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/cas.14527 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: SAA1 (日)
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| 4. | (英) KeywordList.Keyword: cancer microenvironment (日)
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| 5. | (英) KeywordList.Keyword: cancer-associated adipocytes (日)
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| 6. | (英) KeywordList.Keyword: metastasis (日)
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| 7. | (英) KeywordList.Keyword: pancreatic cancer (日)
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