| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 田中 宏典 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.消化器内科])
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 3. | 佐藤 康史 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域消化器・総合内科学])
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| 4. | 田中 貴大
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 友成 哲
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 中村 文香
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| ○学籍番号 (推奨): | □ | ****
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| 7. | 藤野 泰輝
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| ○学籍番号 (推奨): | □ | ****
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| 8. | 三井 康裕 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○学籍番号 (推奨): | □ | ****
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| 9. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 10. | 六車 直樹
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| 11. | 森田 明典 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.医用理工学])
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| 12. | 生島 仁史 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.放射線治療学])
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| 13. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Synergistic anti-tumor activity of miriplatin and radiation through PUMA-mediated apoptosis in hepatocellular carcinoma. (日)
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| ○要約 (任意): | □ | (英) The prognosis for patients with unresectable advanced hepatocellular carcinoma (HCC) is poor. Miriplatin is a hydrophobic platinum compound that has a long retention time in lesions after transarterial chemoembolization (TACE). We investigated anti-tumor activity of miriplatin combined with irradiation on HCC cells, and its underlying mechanism of apoptosis. We also analyzed the effectiveness of miriplatin-TACE and radiotherapy for locally advanced HCC. Human HCC cell lines HepG2 and HuH-7 were treated with DPC (active form of miriplatin) and radiation, and synergy was evaluated using a combination index (CI). Apoptosis-related proteins and cell cycles were analyzed by western blotting and flowcytometry. We retrospectively analyzed treatment outcomes in 10 unresectable HCC patients with vascular/bile duct invasion treated with miriplatin-TACE and radiotherapy. DPC or X-ray irradiation decreased cell viability dose-dependently. DPC plus irradiation decreased cell viability synergistically in both cell lines (CI < 1, respectively). Cleaved PARP expression was induced much more strongly by DPC plus irradiation than by each treatment alone. Expression of p53 up-regulated modulator of apoptosis (PUMA) was significantly induced by the combination, and knockdown of PUMA with siRNA significantly decreased apoptosis in both cell lines. DPC plus irradiation caused sub-G1, G2/M, and S phase cell arrest in those cells. The combination of miriplatin-TACE and radiotherapy showed a high response rate for patients with locally advanced HCC despite small number of patients. Miriplatin plus irradiation had synergistic anti-tumor activity on HCC cells through PUMA-mediated apoptosis and cell cycle arrest. This combination may possibly be effective in treating locally advanced HCC. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Gastroenterology ([財団法人 日本消化器病学会])
(pISSN: 0944-1174, eISSN: 1435-5922)
| ○ISSN (任意): | □ | 1435-5922
ISSN: 0944-1174
(pISSN: 0944-1174, eISSN: 1435-5922) Title: Journal of gastroenterologyTitle(ISO): J GastroenterolSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
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| ○巻 (必須): | □ | 55
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 1072 1086
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| ○年月日 (必須): | □ | 西暦 2020年 7月 14日 (令和 2年 7月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00535-020-01705-8 (→Scopusで検索)
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| ○PMID (任意): | □ | 32666201 (→Scopusで検索)
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| ○CRID (任意): |
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| ○Scopus (任意): | □ | 2-s2.0-85087895196
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s00535-020-01705-8 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Apoptosis (日)
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| 4. | (英) KeywordList.Keyword: Hepatocellular carcinoma (日)
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| 5. | (英) KeywordList.Keyword: Miriplatin (日)
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| 6. | (英) KeywordList.Keyword: Radiation (日)
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| 7. | (英) KeywordList.Keyword: Synergistic effect (日)
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