『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=366058EID:366058, Map:0, LastModified:2020年11月28日(土) 20:28:39, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐田 政隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨):
著者 (必須): 1. (英) Rahadian Arief (日) Arief Rahadian (読) ありえふ らはでぃあん
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学籍番号 (推奨): **** [ユーザ]
[継承]
2.福田 大受 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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3. (英) Salim HM (日) (読)
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4.八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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5.楠瀬 賢也 ([徳島大学.病院.診療科.内科.循環器内科])
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6.山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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7.添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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8.佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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題名 (必須): (英) Canagliflozin Prevents Diabetes-Induced Vascular Dysfunction in ApoE-Deficient Mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) Recent studies have demonstrated that selective sodium-glucose cotransporter 2 inhibitors (SGLT2is) reduce cardiovascular events, although their mechanism remains obscure. We examined the effect of canagliflozin, an SGLT2i, on atherogenesis and investigated its underlying mechanism. Canagliflozin (30 mg/kg/day) was administered by gavage to streptozotocin-induced diabetic apolipoprotein E-deficient (ApoE) mice. Sudan IV staining was performed at the aortic arch. Immunostaining, quantitative RT-PCR, and vascular reactivity assay were performed using the aorta. In vitro experiments using human umbilical vein endothelial cells (HUVECs) were also performed. Canagliflozin decreased blood glucose (P<0.001) and total cholesterol (P<0.05) levels. Sudan IV staining showed that 12-week canagliflozin treatment decreased atherosclerotic lesions (P<0.05). Further, 8-week canagliflozin treatment ameliorated endothelial dysfunction, as determined by acetylcholine-induced vasodilation (P<0.05), and significantly reduced the expressions of inflammatory molecules such as ICAM-1 and VCAM-1 in the aorta at the RNA and protein levels. Canagliflozin also reduced the expressions of NADPH oxidase subunits such as NOX2 and p22phox in the aorta and reduced urinary excretion of 8-OHdG, suggesting a reduction in oxidative stress. Methylglyoxal, a precursor of advanced glycation end products, increased the expressions of ICAM-1 and p22phox in HUVECs (P<0.05, both). Methylglyoxal also decreased the phosphorylation of eNOS and Akt but increased the phosphorylation of eNOS and p38 MAPK in HUVECs. Canagliflozin prevents endothelial dysfunction and atherogenesis in diabetic ApoE mice. Anti-inflammatory and antioxidative potential due to reduced glucose toxicity to endothelial cells might be its underlying mechanisms.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Journal of Atherosclerosis and Thrombosis (日本動脈硬化学会)
(pISSN: 1340-3478, eISSN: 1880-3873)

ISSN (任意): 1880-3873
ISSN: 1340-3478 (pISSN: 1340-3478, eISSN: 1880-3873)
Title: Journal of atherosclerosis and thrombosis
Title(ISO): J Atheroscler Thromb
Supplier: 一般社団法人 日本動脈硬化学会
Publisher: Japan Atherosclerosis Society
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 27 [継承]
(必須): 11 [継承]
(必須): 1141 1151 [継承]
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年月日 (必須): 西暦 2020年 2月 26日 (令和 2年 2月 26日) [継承]
URL (任意):
DOI (任意): 10.5551/jat.52100    (→Scopusで検索) [継承]
PMID (任意): 32101837    (→Scopusで検索) [継承]
NAID (任意): 130007933946 [継承]
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指導教員 (推奨): 1.佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学]) [継承]
備考 (任意): 1.(英) Article.ELocationID: 10.5551/jat.52100  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: Atherosclerosis  (日)    [継承]
4.(英) KeywordList.Keyword: Canagliflozin  (日)    [継承]
5.(英) KeywordList.Keyword: Endothelial dysfunction  (日)    [継承]
6.(英) KeywordList.Keyword: SGLT2 inhibitor  (日)    [継承]

標準的な表示

和文冊子 ● Arief Rahadian, Daiju Fukuda, HM Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Canagliflozin Prevents Diabetes-Induced Vascular Dysfunction in ApoE-Deficient Mice, Journal of Atherosclerosis and Thrombosis, Vol.27, No.11, 1141-1151, 2020.
欧文冊子 ● Arief Rahadian, Daiju Fukuda, HM Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Canagliflozin Prevents Diabetes-Induced Vascular Dysfunction in ApoE-Deficient Mice, Journal of Atherosclerosis and Thrombosis, Vol.27, No.11, 1141-1151, 2020.

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