| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 山口 泉
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| 2. | 兼松 康久
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| ○学籍番号 (推奨): |
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| 3. | 島田 健司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 高麗 雅章 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| [継承] |
| 5. | 宮本 健志 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| ○学籍番号 (推奨): |
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| 6. | (英) Shikata Eiji (日) 四方 英二 (読) しかた えいじ
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| ○学籍番号 (推奨): | □ | ****
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| 7. | (英) Yamaguchi Tadashi (日) 山口 真司 (読) やまぐち ただし
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 8. | 山本 伸昭
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| [継承] |
| 9. | (英) Yamamoto Yuki (日) 山本 雄貴 (読) やまもと ゆうき
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 10. | (英) Kitazato Keiko (日) 北里 慶子 (読) きたざと けいこ
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) Okayama Yoshihiro (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | 髙木 康志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Active Cancer and Elevated D-Dimer Are Risk Factors for In-Hospital Ischemic Stroke (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Little attention has been paid to the pathogenesis of in-hospital stroke, despite poor outcomes and a longer time from stroke onset to treatment. We studied the pathophysiology and biomarkers for detecting patients who progress to in-hospital ischemic stroke (IHS). Seventy-nine patients with IHS were sequentially recruited in the period 2011-2017. Their characteristics, care, and outcomes were compared with 933 patients who had an out-of-hospital ischemic stroke (OHS) using a prospectively collected database of the Tokushima University Stroke Registry. Active cancer and coronary artery disease were more prevalent in patients with IHS than in those with OHS (53.2 and 27.8% vs. 2.0 and 10.9%, respectively; p < 0.001), the median onset-to-evaluation time was longer (300 vs. 240 min; p = 0.015), and the undetermined etiology was significantly higher (36.7 vs. 2.4%; p < 0.001). Although there was no significant difference in stroke severity at onset between the groups, patients with IHS had higher modified Rankin Scale (mRS) scores (3-6) at discharge (67.1 vs. 50.3%; p = 0.004) and rates of death during hospitalization (16.5 vs. 2.9%; p < 0.001). D-dimer (5.8 vs. 0.8 µg/mL; p < 0.001) and fibrinogen (532 vs. 430 mg/dL; p = 0.014) plasma levels at the time of onset were significantly higher in patients with IHS after propensity score matching. Multivariate logistic regression analysis revealed that active cancer (odds ratio [OR] 2.30; 95% confidence interval [CI] 1.26-4.20), prestroke mRS scores 3-5 (OR 6.78; 95% CI 3.96-11.61), female sex (OR 1.57; 95% CI 1.19-2.08), and age ≥75 years (OR 2.36; 95% CI 1.80-3.08) were associated with poor outcomes. Patients with IHS had poorer outcomes than those with OHS because of a higher prevalence of active cancer and functional dependence before stroke onset. Elevated plasma levels of D-dimer and fibrinogen, especially with active cancer, can help identify patients who are at a higher risk of progression to IHS. (日)
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| ○キーワード (推奨): | 1. | (英) Aged (日) (読)
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| 2. | (英) Aged, 80 and over (日) (読)
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| 3. | (英) Biomarkers (日) (読)
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| 4. | (英) Brain Ischemia (日) (読)
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| 5. | (英) Databases, Factual (日) (読)
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| 6. | 女性 (female)
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| 7. | (英) Fibrin Fibrinogen Degradation Products (日) (読)
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| 8. | (英) Hospital Mortality (日) (読)
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| 9. | (英) Hospitalization (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Inpatients (日) (読)
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| 12. | 日本 (Japan)
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| 13. | 男性 (male)
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| 14. | (英) Middle Aged (日) (読)
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| 15. | (英) Neoplasms (日) (読)
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| 16. | (英) Prevalence (日) (読)
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| 17. | (英) Prognosis (日) (読)
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| 18. | (英) Registries (日) (読)
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| 19. | (英) Retrospective Studies (日) (読)
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| 20. | (英) Risk Assessment (日) (読)
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| 21. | (英) Risk Factors (日) (読)
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| 22. | (英) Stroke (日) (読)
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| 23. | (英) Time Factors (日) (読)
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| 24. | (英) Up-Regulation (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cerebrovascular Diseases Extra
(eISSN: 1664-5456)
| ○ISSN (任意): | □ | 1664-5456
ISSN: 1664-5456
(eISSN: 1664-5456) Title: Cerebrovascular diseases extraTitle(ISO): Cerebrovasc Dis ExtraPublisher: S. Karger AG (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 9
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 129 138
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 11月 22日 (令和 元年 11月 22日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1159/000504163 (→Scopusで検索)
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| ○PMID (任意): | □ | 31760390 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85075786196
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1159/000504163 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Cancer (日)
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| 4. | (英) KeywordList.Keyword: D-dimer (日)
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| 5. | (英) KeywordList.Keyword: Fibrinogen (日)
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| 6. | (英) KeywordList.Keyword: Hypercoagulability (日)
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| 7. | (英) KeywordList.Keyword: In-hospital stroke (日)
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