『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=363392EID:363392, Map:0, LastModified:2020年4月21日(火) 21:33:07, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[吉田 賀弥], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
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著者 (必須): 1. (英) Sumitani Yusuke (日) (読)
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2. (英) Uchibe Kenta (日) (読)
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[継承]
3.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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4. (英) Weng Yao (日) (読)
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[継承]
5. (英) Guo Jiajie (日) (読)
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6. (英) Yuan Haoze (日) (読)
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[継承]
7. (英) Ikegame Mika (日) (読)
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8. (英) Kamioka Hiroshi (日) (読)
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9.岡村 裕彦
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[継承]
題名 (必須): (英) Inhibitory effect of retinoic acid receptor agonists on in vitro chondrogenic differentiation.  (日)    [継承]
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要約 (任意): (英) Retinoic acid (RA), an active metabolite of vitamin A, plays pivotal roles in a wide variety of biological processes, such as body patterning, organ development, and cell differentiation and proliferation. RA signaling is mediated by nuclear retinoic acid receptors, α, β, and γ (RARα, RARβ, and RARγ). RA is a well-known regulator of cartilage and skeleton formation and RARs are also essential for skeletal growth and hypertrophic chondrocyte-specific gene expression. These important roles of RA and RARs in chondrogenesis have been widely investigated using in vivo mouse models. However, few reports are available on the function of each subtype of RARs on in vitro chondrocyte differentiation. Here, we examined the effect of specific agonists of RARs on chondrogenic differentiation of ATDC5 and C3H10T1/2 cells. Subtype-specific RAR agonists as well as RA decreased the expressions of chondrogenic differentiation marker genes and inhibited chondrogenic differentiation, which was accompanied with morphological change to spindle-shaped cells. Among RAR agonists, RARα and RARγ agonists revealed a strong inhibitory effect on chondrogenic differentiation. RARα and RARγ agonists also hampered viability of ATDC5 cells. These observations suggested that RARα and RARγ are dominant receptors of RA signaling that negatively regulate chondrogenic differentiation.  (日)    [継承]
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誌名 (必須): Anatomical Science International ([社団法人 日本解剖学会])
(pISSN: 1447-6959, eISSN: 1447-073X)

ISSN (任意): 1447-073X
ISSN: 1447-6959 (pISSN: 1447-6959, eISSN: 1447-073X)
Title: Anatomical science international
Title(ISO): Anat Sci Int
Publisher: Springer Japan
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2020年 3月 初日 (令和 2年 3月 初日) [継承]
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DOI (任意): 10.1007/s12565-019-00512-3    (→Scopusで検索) [継承]
PMID (任意): 31732869    (→Scopusで検索) [継承]
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標準的な表示

和文冊子 ● Yusuke Sumitani, Kenta Uchibe, Kaya Yoshida, Yao Weng, Jiajie Guo, Haoze Yuan, Mika Ikegame, Hiroshi Kamioka and Hirohiko Okamura : Inhibitory effect of retinoic acid receptor agonists on in vitro chondrogenic differentiation., Anatomical Science International, Vol.95, No.2, 202-208, 2020.
欧文冊子 ● Yusuke Sumitani, Kenta Uchibe, Kaya Yoshida, Yao Weng, Jiajie Guo, Haoze Yuan, Mika Ikegame, Hiroshi Kamioka and Hirohiko Okamura : Inhibitory effect of retinoic acid receptor agonists on in vitro chondrogenic differentiation., Anatomical Science International, Vol.95, No.2, 202-208, 2020.

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