『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=363391)

EID=363391EID:363391, Map:0, LastModified:2020年4月21日(火) 21:33:43, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[吉田 賀弥], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
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著者 (必須): 1. (英) Guo Jiajie (日) (読)
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2.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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3. (英) Ikegame Mika (日) (読)
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4.岡村 裕彦
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題名 (必須): (英) Quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone: An all-rounder in mammalian cell modification.  (日)    [継承]
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要約 (任意): (英) BACKGROUND: Bacteria exhibit multi-cellular social behavior, such as biofilm formation, virulence generation, bioluminescence, or sporulation, through cell-to-cell communication involving a quorum sensing (QS) system capable of sensing species density. Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous gram-negative opportunistic pathogen that is frequently isolated from immunocompromised patients. It is particularly detected in patients with severe periodontitis and persistent endodontic infections, forcing a rethink of the role of this opportunistic pathogen in oral lesions.HIGHLIGHT: N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) is a pivotal QS molecule, which regulates numerous virulence genes in P. aeruginosa and exhibits broad biological modulation effects in mammalian cells. In this review, we highlight the diverse OdDHL-mediated apoptosis and immunomodulatory effects on host cells. The structural properties, signaling pathways, targeted genes and proteins, and intracellular metabolism of OdDHL are also discussed to clarify the interactions between P. aeruginosa and the host.CONCLUSION: The purpose of this review is to identify a valid target for quenching OdDHL, which could potentially eliminate the pathogenic effect of P. aeruginosa.  (日)    [継承]
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誌名 (必須): Journal of Oral Biosciences ([歯科基礎医学会])
(pISSN: 1349-0079, eISSN: 1880-3865)

ISSN (任意): 1349-0079
ISSN: 1349-0079 (pISSN: 1349-0079, eISSN: 1880-3865)
Title: Journal of oral biosciences
Title(ISO): J Oral Biosci
Supplier: 歯科基礎医学会
Publisher: Japanese Association for Oral Biology
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): S1349-0079 [継承]
(必須): (20) [継承]
(必須): 30001 30003 [継承]
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年月日 (必須): 西暦 2020年 2月 20日 (令和 2年 2月 20日) [継承]
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DOI (任意): 10.1016/j.job.2020.01.001    (→Scopusで検索) [継承]
PMID (任意): 31982630    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85078818697 [継承]
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標準的な表示

和文冊子 ● Jiajie Guo, Kaya Yoshida, Mika Ikegame and Hirohiko Okamura : Quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone: An all-rounder in mammalian cell modification., Journal of Oral Biosciences, Vol.S1349-0079, No.(20), 30001-30003, 2020.
欧文冊子 ● Jiajie Guo, Kaya Yoshida, Mika Ikegame and Hirohiko Okamura : Quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone: An all-rounder in mammalian cell modification., Journal of Oral Biosciences, Vol.S1349-0079, No.(20), 30001-30003, 2020.

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