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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.松本 穣 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.分子病理学])
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2.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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3.森本 純子 ([徳島大学.先端酵素学研究所.重点研究部門])
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4. (英) Hosomichi Kazuyoshi (日) (読)
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5.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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6.西嶋 仁
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題名 (必須): (英) Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms.  (日)    [継承]
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要約 (任意): (英) Tissue-specific autoimmune diseases are assumed to arise through malfunction of two checkpoints for immune tolerance: defective elimination of autoreactive T cells in the thymus and activation of these T cells by corresponding autoantigens in the periphery. However, evidence for this model and the outcome of such alterations in each or both of the tolerance mechanisms have not been sufficiently investigated. We studied these issues by expressing human AIRE (huAIRE) as a modifier of tolerance function in NOD mice wherein the defects of thymic and peripheral tolerance together cause type I diabetes (T1D). Additive huAIRE expression in the thymic stroma had no major impact on the production of diabetogenic T cells in the thymus. In contrast, huAIRE expression in peripheral antigen-presenting cells (APCs) rendered the mice resistant to T1D, while maintaining other tissue-specific autoimmune responses and antibody production against an exogenous protein antigen, because of the loss of Xcr1+ dendritic cells, an essential component for activating diabetogenic T cells in the periphery. These results contrast with our recent demonstration that huAIRE expression in both the thymic stroma and peripheral APCs resulted in the paradoxical development of muscle-specific autoimmunity. Our results reveal that tissue-specific autoimmunity is differentially controlled by a combination of thymic function and peripheral tolerance, which can be manipulated by expression of huAIRE/Aire in each or both of the tolerance mechanisms.  (日)    [継承]
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誌名 (必須): International Immunology ([Oxford University Press])
(pISSN: 0953-8178, eISSN: 1460-2377)

ISSN (任意): 1460-2377
ISSN: 0953-8178 (pISSN: 0953-8178, eISSN: 1460-2377)
Title: International immunology
Title(ISO): Int Immunol
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2020年 2月 7日 (令和 2年 2月 7日) [継承]
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DOI (任意): 10.1093/intimm/dxz066    (→Scopusで検索) [継承]
PMID (任意): 31586207    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Minoru Matsumoto, Koichi Tsuneyama, Junko Morimoto, Kazuyoshi Hosomichi, Mitsuru Matsumoto and Hitoshi Nishijima : Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms., International Immunology, Vol.32, No.2, 117-131, 2020.
欧文冊子 ● Minoru Matsumoto, Koichi Tsuneyama, Junko Morimoto, Kazuyoshi Hosomichi, Mitsuru Matsumoto and Hitoshi Nishijima : Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms., International Immunology, Vol.32, No.2, 117-131, 2020.

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