| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 髙岡 勝吉 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| ○学籍番号 (推奨): |
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| 2. | (英) Yamamoto Masamichi (日) (読)
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| 3. | (英) Hamada Hiroshi (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Origin and role of distal visceral endoderm, a group of cells that determines anterior-posterior polarity of the mouse embryo. (日)
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| ○要約 (任意): | □ | (英) Anterior-posterior polarity of the mouse embryo has been thought to be established when distal visceral endoderm (DVE) at embryonic day (E) 5.5 migrates toward the future anterior side to form anterior visceral endoderm (AVE). Lefty1, a marker of DVE and AVE, is asymmetrically expressed in implanting mouse embryos. We now show that Lefty1 is expressed first in a subset of epiblast progenitor cells and then in a subset of primitive endoderm progenitors. Genetic fate mapping indicated that the latter cells are destined to become DVE. In contrast to the accepted notion, however, AVE is not derived from DVE but is newly formed after E5.5 from Lefty1(-) visceral endoderm cells that move to the distal tip. Concomitant with DVE migration, all visceral endoderm cells in the embryonic region undergo global movement. In embryos subjected to genetic ablation of Lefty1-expressing DVE cells, AVE was formed de novo but the visceral endoderm including the newly formed AVE failed to migrate, indicating that DVE guides the migration of AVE by initiating the global movement of visceral endoderm cells. Future anterior-posterior polarity is thus already determined by Lefty1(+) blastomeres in the implanting blastocyst. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Blastocyst (日) (読)
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| 3. | (英) Blastomeres (日) (読)
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| 4. | 細胞分化 (cell differentiation)
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| 5. | (英) Cell Lineage (日) (読)
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| 6. | (英) Cell Movement (日) (読)
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| 7. | (英) Cell Polarity (日) (読)
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| 8. | 細胞質分裂 (cytokinesis)
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| 9. | (英) Embryo, Mammalian (日) (読)
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| 10. | (英) Embryonic Stem Cells (日) (読)
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| 11. | (英) Endoderm (日) (読)
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| 12. | (英) Gene Expression Regulation, Developmental (日) (読)
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| 13. | (英) Gestational Age (日) (読)
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| 14. | (英) In Situ Hybridization (日) (読)
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| 15. | (英) Left-Right Determination Factors (日) (読)
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| 16. | (英) Mice (日) (読)
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| 17. | (英) Mice, Transgenic (日) (読)
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| 18. | (英) Microscopy, Fluorescence (日) (読)
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| 19. | (英) Microscopy, Video (日) (読)
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| 20. | 形態形成 (morphogenesis)
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| 21. | (英) Proteins (日) (読)
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| 22. | (英) Recombinant Fusion Proteins (日) (読)
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| 23. | (英) Time Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Cell Biology ([Nature Publishing Group])
(pISSN: 1465-7392, eISSN: 1476-4679)
| ○ISSN (任意): | □ | 1476-4679
ISSN: 1465-7392
(pISSN: 1465-7392, eISSN: 1476-4679) Title: Nature cell biologyTitle(ISO): Nat Cell BiolPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 13
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 743 752
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 5月 29日 (平成 23年 5月 29日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/ncb2251 (→Scopusで検索)
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| ○PMID (任意): | □ | 21623358 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-79960026099
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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| 3. | (英) PublicationType: Video-Audio Media (日)
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