| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 蔵本 瞳 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.小児歯科学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| 2. | 平尾 功治
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| ○学籍番号 (推奨): | □ | ****
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| 3. | 湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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| 4. | 細川 由樹 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| 5. | 中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.⻭科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| ○学籍番号 (推奨): |
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| 6. | 武川 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.⻭科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| [継承] |
| 7. | (英) Washio Ayako (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Kitamura Chiaki (日) (読)
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| [継承] |
| 9. | 松尾 敬志
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Caffeic acid phenethyl ester (CAPE) induces VEGF expression and production in rat odontoblastic cells (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries. In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflammation caused by dental caries. CAPE significantly induced mRNA expression and production of VEGF in rat clonal odontoblast-like KN-3 cells cultured in normal medium or osteogenic induction medium. CAPE treatment enhanced nuclear factor-kappa B (NF-B) transcription factor activation, and furthermore, the specific inhibitor of NF-B significantly reduced VEGF production. The expression of VEGF receptor- (VEGFR-) 2, not VEGFR-1, was up regulated in KN-3 cells treated with CAPE. In addition, VEGF significantly increased mineralization activity in KN-3 cells. These findings suggest that CAPE might be useful as a novel biological material for the dental pulp conservative therapy. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | BioMed Research International (Hindawi Pub. Co.)
(pISSN: 2314-6133, eISSN: 2314-6141)
| ○ISSN (任意): | □ | 2314-6133
ISSN: 2314-6133
(pISSN: 2314-6133, eISSN: 2314-6141) Title: BioMed research internationalTitle(ISO): Biomed Res IntPublisher: Hindawi (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | Article ID 5390720
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ |
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 12月 20日 (令和 元年 12月 20日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1155/2019/5390720 (→Scopusで検索)
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| ○PMID (任意): | □ | 31930126 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85077441042
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1155/2019/5390720 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) CoiStatement: The authors declare that there are no conflicts of interest. (日)
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