| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
| [継承] |
| ○カテゴリ (推奨): | □ | 研究
| [継承] |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 福本 誠二
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 髙士 祐一
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | Tsoumpra Maria ([国立精神・神経医療センター])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 沢津橋 俊 ([徳島大学.先端酵素学研究所.技術開発支援部門])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 松本 俊夫
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) How do we sense phosphate to regulate serum phosphate level? (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Abnormal phosphate levels result in several pathological conditions such as rickets/osteomalacia and ectopic calcification indicating that there must be a system that regulates phosphate level within a narrow range. FGF23 has been shown to be an essential hormone regulating serum phosphate level. FGF23 binds to Klotho-FGF receptor complex to reduce serum phosphate level. Several reports suggested that FGF receptor is involved in the regulation of FGF23 production. It has been also shown that high extracellular phosphate can activate several intracellular signaling pathways. However, it has been unclear whether and how phosphate regulates FGF23 production in vivo. Our recent results indicate that high extracellular phosphate directly activates FGF receptor 1 and the downstream intracellular signaling enhances FGF23 production. Thus, there is a negative feedback system for the regulation of serum phosphate level involving FGF receptor and FGF23. We propose that FGF receptor works at least as one of phosphate sensors in the maintenance of serum phosphate level. (日)
| [継承] |
| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Bone and Mineral Metabolism ([Springer-Verlag])
(pISSN: 0914-8779, eISSN: 1435-5604)
| ○ISSN (任意): | □ | 1435-5604
ISSN: 0914-8779
(pISSN: 0914-8779, eISSN: 1435-5604) Title: Journal of bone and mineral metabolismTitle(ISO): J Bone Miner MetabSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 38
| [継承] |
| ○号 (必須): | □ | 1
| [継承] |
| ○頁 (必須): | □ | 1 6
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 1月 3日 (令和 2年 1月 3日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00774-019-01066-0 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 31797064 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s00774-019-01066-0 (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Review (日)
| [継承] |
| 4. | (英) KeywordList.Keyword: FGF receptor (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: FGF23 (日)
| [継承] |
| 6. | (英) KeywordList.Keyword: Phosphate (日)
| [継承] |