| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
| [継承] |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
| [継承] |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 福田 達也
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Hirai Shota (日) 平井 将太 (読) ひらい しょうた
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 3. | 吉田 達貞
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Maoka T (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Enhancement of antioxidative activity of astaxanthin by combination with an antioxidant capable of forming intermolecular interactions (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) We previously demonstrated that coencapsulation of the potent antioxidant astaxanthin (Asx) and tocotrienols into liposomes results in synergistically higher antioxidative activity than the calculated additive activity of each individual antioxidant-containing liposome, due to intermolecular interactions between terminal ring moieties of the two antioxidants and the polyene chain and the triene moiety. We reported that intermolecular interactions depend on the stereochemistry of Asx, and change the electronic state of the Asx polyene moiety. Based on these findings, we hypothesised that antioxidants that interact with Asx at the terminal ring and polyene moieties may enhance the antioxidative activity. Herein, we selected two candidate antioxidants, capsaicin (Cap) and resveratrol, based on their structures, in which the compounds exhibit similar characteristics to tocotrienols. We evaluated the antioxidative capacities of liposomes coencapsulating Asx and the selected candidates. Based on hydroxyl radical scavenging activity, Cap was found to synergistically enhance the antioxidative activity of Asx at an optimal Asx/Cap ratio. Intermolecular interactions between Asx and Cap are necessary for the synergistic effect, and the Asx stereoisomer 3,3'-form (Asx-) was predicted to most potently interact. Liposomes coencapsulating Asx- and Cap exhibited clear synergistic antioxidative activity at an optimal ratio, whereas liposomes coencapsulating the other Asx stereoisomer and Cap did not demonstrate such activity. Computational chemistry analysis showed that changes in the electronic state of the polyene moiety of Asx- are crucial for the synergistic activity. These results suggest that antioxidants that can change the electronic state of Asx via intermolecular interactions may enhance the function of Asx. (日)
| [継承] |
| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Free Radical Research (Society for Free Radical Research - Europe/Society for Free Radical Research - Asia)
(pISSN: 1071-5762, eISSN: 1029-2470)
| ○ISSN (任意): | □ | 1029-2470
ISSN: 1071-5762
(pISSN: 1071-5762, eISSN: 1029-2470) Title: Free radical researchTitle(ISO): Free Radic ResPublisher: Taylor & Francis (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ |
| [継承] |
| ○号 (必須): | □ |
| [継承] |
| ○頁 (必須): | □ |
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 3月 5日 (令和 2年 3月 5日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1080/10715762.2019.1693042 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 31718328 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85081234098
| [継承] |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1080/10715762.2019.1693042 (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) KeywordList.Keyword: Antioxidants (日)
| [継承] |
| 4. | (英) KeywordList.Keyword: astaxanthin (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: capsaicin (日)
| [継承] |
| 6. | (英) KeywordList.Keyword: intermolecular interactions (日)
| [継承] |
| 7. | (英) KeywordList.Keyword: liposomes (日)
| [継承] |
| 8. | (英) KeywordList.Keyword: stereochemistry (日)
| [継承] |