『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=360418EID:360418, Map:0, LastModified:2019年10月18日(金) 15:21:09, Operator:[山下 理子], Avail:TRUE, Censor:0, Owner:[山下 理子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.山下 理子 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.病理解析学])
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[継承]
2. (英) Fujii Yoshiyuki (日) (読)
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[継承]
3. (英) Ozaki Keiji (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Urano Yoshio (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Iwasa Masami (日) 岩佐 昌美 (読) いわさ まさみ
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学籍番号 (推奨): **** [ユーザ]
[継承]
6.中村 信元 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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学籍番号 (推奨):
[継承]
7.藤井 志朗 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.血液内科])
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学籍番号 (推奨): **** [ユーザ]
[継承]
8.安倍 正博 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
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学籍番号 (推奨):
[継承]
9. (英) Sato Yasuharu (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Yoshino Tadashi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Human immunodeficiency virus-positive secondary syphilis mimicking cutaneous T-cell lymphoma.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Malignant syphilis or lues maligna is a severe form of secondary syphilis that was commonly reported in the pre-antibiotic era, and has now reemerged with the advent of the human immunodeficiency virus (HIV) epidemic. However, the characteristic histopathological findings of malignant syphilis remain controversial. The aim of this case report was to clarify the clinical and histopathological findings of HIV-positive malignant secondary syphilis. A Japanese man in his forties complained of fever, skin lesions, headache, and myalgia without lymphadenopathy during the previous 4 weeks. The skin lesions manifested as erythematous, nonhealing, ulcerated papules scattered on his trunk, extremities, palm, and face. Although the skin lesions were suspected to be cutaneous T-cell lymphomas on histological analyses, they lacked T-cell receptor Jγ rearrangement; moreover, immunohistochemical analyses confirmed the presence of spirochetes. The patient was administered antibiotics and anti-retroviral therapy, which dramatically improved the symptoms. On the basis of these observations of the skin lesions, we finally diagnosed the patient with HIV-associated secondary syphilis that mimicked cutaneous T-cell lymphoma. The patient's systemic CD4+ lymphocyte count was very low, and the infiltrate was almost exclusively composed of CD8+ atypical lymphocytes; therefore, the condition was easily misdiagnosed as cutaneous lymphoma. Although the abundance of plasma cells is a good indicator of malignant syphilis on skin histological analyses, in some cases, the plasma cell count may be very low. Therefore, a diagnosis of malignant secondary syphilis should be considered before making a diagnosis of primary cutaneous peripheral T-cell lymphoma or lymphoma associated with HIV infection.  (日)    [継承]
キーワード (推奨): 1. (英) AIDS-Related Opportunistic Infections (日) (読) [継承]
2. (英) Anti-Bacterial Agents (日) (読) [継承]
3. (英) Anti-HIV Agents (日) (読) [継承]
4. (英) Biopsy (日) (読) [継承]
5. (英) Coinfection (日) (読) [継承]
6. (英) Diagnosis, Differential (日) (読) [継承]
7. (英) HIV Infections (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9.免疫組織化学 (immunohistochemistry) [継承]
10. (英) Lymphoma, T-Cell, Cutaneous (日) (読) [継承]
11.男性 (male) [継承]
12. (英) Predictive Value of Tests (日) (読) [継承]
13.皮膚 (skin) [継承]
14. (英) Skin Neoplasms (日) (読) [継承]
15. (英) Syphilis (日) (読) [継承]
16. (英) Syphilis, Cutaneous (日) (読) [継承]
17. (英) Treatment Outcome (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Diagnostic Pathology ([BioMed Central Ltd.])
(eISSN: 1746-1596)

ISSN (任意): 1746-1596
ISSN: 1746-1596 (eISSN: 1746-1596)
Title: Diagnostic pathology
Title(ISO): Diagn Pathol
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 10 [継承]
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(必須): 185 185 [継承]
都市 (任意):
年月日 (必須): 西暦 2015年 10月 8日 (平成 27年 10月 8日) [継承]
URL (任意):
DOI (任意): 10.1186/s13000-015-0419-5    (→Scopusで検索) [継承]
PMID (任意): 26449225    (→Scopusで検索) [継承]
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WOS (任意): 000362470800001 [継承]
Scopus (任意): 2-s2.0-84943540407 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1186/s13000-015-0419-5  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Case Reports  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) SupplMeshList.SupplMeshName: Syphilis, secondary  (日)    [継承]
5.(英) OtherID: PMC4599588  (日)    [継承]

標準的な表示

和文冊子 ● Michiko Yamashita, Yoshiyuki Fujii, Keiji Ozaki, Yoshio Urano, Masami Iwasa, Shingen Nakamura, Shiroh Fujii, Masahiro Abe, Yasuharu Sato and Tadashi Yoshino : Human immunodeficiency virus-positive secondary syphilis mimicking cutaneous T-cell lymphoma., Diagnostic Pathology, Vol.10, (号), 185, 2015.
欧文冊子 ● Michiko Yamashita, Yoshiyuki Fujii, Keiji Ozaki, Yoshio Urano, Masami Iwasa, Shingen Nakamura, Shiroh Fujii, Masahiro Abe, Yasuharu Sato and Tadashi Yoshino : Human immunodeficiency virus-positive secondary syphilis mimicking cutaneous T-cell lymphoma., Diagnostic Pathology, Vol.10, (号), 185, 2015.

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