『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=359947EID:359947, Map:0, LastModified:2020年2月1日(土) 20:37:55, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[大東 いずみ], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨): 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Khanom Umme Shahina (日) UMME KHANOM SHAHINA (読) うめ かのん しゃひな
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学籍番号 (推奨): **** [ユーザ]
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2.大東 いずみ ([徳島大学.先端酵素学研究所.重点研究部門])
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3.藤森 さゆ美 ([徳島大学.先端酵素学研究所.重点研究部門])
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4.近藤 健太
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5.高田 健介
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6.高浜 洋介
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題名 (必須): (英) TCR affinity for in vivo peptide-induced thymic positive selection fine-tunes TCR responsiveness of peripheral CD8+ T cells  (日)    [継承]
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要約 (任意): (英) The affinity for TCR interactions with self-peptide/MHC complexes (pMHC) in the thymus critically affects immature thymocytes that newly express TCRs. Previous fetal thymus organ culture experiments have indicated that difference in the affinity for thymic TCR/pMHC interactions not only determines thymocyte fate between positive and negative selection, but also affects Ag responsiveness of positively selected thymocytes. In the current study, we examined whether TCR/pMHC affinity during positive selection in the thymus would further affect Ag responsiveness of mature T cells in the periphery. To do so, OVA peptide variants were in vivo administered to TAP1-deficient OT-I/TCR-transgenic mice in which T cell development was otherwise arrested at CD4CD8 thymocytes because of the lack of self-pMHC presentation in thymic APCs. We found that a group of peptide variants induced the transient generation of OT-I CD8 T cells in the thymus and the periphery. We also noticed that the affinity threshold for positive and negative selection detected in adult mice in vivo was higher than that measured in fetal thymus organ culture experiments in vitro. Interestingly, we further found that the affinity for positively selecting peptides proportionally affected TCR responsiveness of peripheral naive CD8 T cells. These results indicate that in vivo administration of a peptide can promote T cell selection in the thymus and the affinity for TCR/pMHC interaction during positive selection fine-tunes Ag responsiveness of peripheral T cells.  (日)    [継承]
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誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
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年月日 (必須): 西暦 2019年 8月 15日 (令和 元年 8月 15日) [継承]
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DOI (任意): 10.4049/jimmunol.1900097    (→Scopusで検索) [継承]
PMID (任意): 31235550    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85070388863 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.4049/jimmunol.1900097  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Shahina Umme Khanom, Izumi Ohigashi, Sayumi Fujimori, Kenta Kondou, Kensuke Takada and Yousuke Takahama : TCR affinity for in vivo peptide-induced thymic positive selection fine-tunes TCR responsiveness of peripheral CD8+ T cells, The Journal of Immunology, Vol.203, No.4, 881-887, 2019.
欧文冊子 ● Shahina Umme Khanom, Izumi Ohigashi, Sayumi Fujimori, Kenta Kondou, Kensuke Takada and Yousuke Takahama : TCR affinity for in vivo peptide-induced thymic positive selection fine-tunes TCR responsiveness of peripheral CD8+ T cells, The Journal of Immunology, Vol.203, No.4, 881-887, 2019.

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