| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 徳島大学以外での国内共著 (徳島大学以外でのある一つの国に属する複数機関による共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kotoda Masakazu (日) (読)
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| 2. | (英) Furukawa Hajime (日) (読)
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| 3. | 宮本 健志 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| 4. | (英) Korai Masaaki (日) (読)
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| [継承] |
| 5. | (英) Shikata Fumiaki (日) (読)
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| 6. | (英) Kuwabara Atsushi (日) (読)
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| 7. | (英) Xiong Xiaoxing (日) (読)
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| 8. | (英) Rutledge Caleb (日) (読)
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| 9. | (英) Giffard G. Rona (日) (読)
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| 10. | (英) Hashimoto Tomoki (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Role of myeloid lineage cell autophagy in ischemic brain injury. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Inflammatory cells play a significant role in secondary injury after ischemic stroke. Recent studies have suggested that a lack of autophagy in myeloid cells causes augmented proinflammatory cytokine release and prolonged inflammation after tissue injury. In this study, we investigated the roles of myeloid cell autophagy in ischemic brain injury. Focal cerebral ischemia was induced via transient middle cerebral artery occlusion in mice with autophagy-deficient myeloid lineage cells (Atg5flox/flox LysMCre+) and in their littermate controls (Atg5flox/flox). Infarct volume, neurological function, inflammatory cell infiltration, and proinflammatory cytokine expression levels were evaluated. Mice lacking autophagy in myeloid lineage cells had a lower survival rate for 14 days than control mice (20% versus 70%; <0.05). Although there was no difference in infarct volume at 12 hours between the 2 groups, mice lacking autophagy in myeloid lineage cells had larger infarct volumes at later time points (3 and 7 days after reperfusion) with worse neurological deficit scores and lower grip test scores. There were a higher number of ionized calcium binding adaptor molecule 1-positive cells and cells expressing M1 marker CD16/32 in mice lacking autophagy in myeloid cells at the later time points. Moreover, these mice had higher expression levels of proinflammatory cytokines at later time points; however, there was no difference in ionized calcium binding adaptor molecule 1-positive cells or mRNA levels of proinflammatory cytokines at the earlier time point (12 hours after reperfusion). These data suggest that the lack of myeloid cell autophagy aggravates secondary injury by augmenting and prolonging inflammation after ischemic stroke without affecting the initial injury. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | オートファジー (autophagy)
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| 3. | 脳 (brain)
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| 4. | (英) Brain Injuries (日) (読)
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| 5. | (英) Brain Ischemia (日) (読)
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| 6. | (英) Cell Lineage (日) (読)
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| 7. | 細胞質分裂 (cytokinesis)
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| 8. | (英) Disease Models, Animal (日) (読)
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| 9. | (英) Infarction, Middle Cerebral Artery (日) (読)
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| 10. | 炎症 (inflammation)
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| 11. | (英) Mice, Transgenic (日) (読)
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| 12. | (英) Myeloid Cells (日) (読)
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| 13. | (英) Stroke (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Stroke ([American Heart Association])
(pISSN: 0039-2499, eISSN: 1524-4628)
| ○ISSN (任意): | □ | 1524-4628
ISSN: 0039-2499
(pISSN: 0039-2499, eISSN: 1524-4628) Title: StrokeTitle(ISO): StrokePublisher: American Heart Association (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 49
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 1488 1495
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 5月 10日 (平成 30年 5月 10日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1161/STROKEAHA.117.018637 (→Scopusで検索)
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| ○PMID (任意): | □ | 29748423 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85061885685
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1161/STROKEAHA.117.018637 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) KeywordList.Keyword: autophagy (日)
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| 6. | (英) KeywordList.Keyword: brain ischemia (日)
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| 7. | (英) KeywordList.Keyword: inflammation (日)
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| 8. | (英) KeywordList.Keyword: myeloid cells (日)
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| 9. | (英) KeywordList.Keyword: stroke (日)
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