『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=359326EID:359326, Map:0, LastModified:2020年9月9日(水) 08:52:46, Operator:[堤 理恵], Avail:TRUE, Censor:0, Owner:[堤 理恵], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Miki Mari (日) (読)
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2.安岡 劭
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3.堤 理恵 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学])
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4. (英) Nakamura Yoichi (日) (読)
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5. (英) Hajime Maeda (日) (読)
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6. (英) Takeuchi Yukiyasu (日) (読)
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7. (英) Miki Keisuke (日) (読)
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8. (英) Kitada Seigo (日) (読)
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9. (英) Maekura Ryoji (日) (読)
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題名 (必須): (英) Human airway trypsin-like protease enhances interleukin-8 synthesis in bronchial epithelial cells by activating protease-activated receptor 2.  (日)    [継承]
副題 (任意):
要約 (任意): (英) bond) of synthetic PAR2 N-terminal peptide. These results indicate that HAT stimulates IL-8 synthesis in airway epithelial cells via PAR2 and could help to amplify inflammation in chronic respiratory tract disease.  (日) Human airway trypsin-like protease (HAT) localizes at human bronchial epithelial cells (HBECs). HAT enhanced release of interleukin-8 (IL-8) from HBECs at 10-100 mU/mL and the enhanced release was almost completely abolished by 50 μM leupeptin, a serine protease inhibitor. Previous reports suggested that HAT displays its physiological functions via protease-activated receptor 2 (PAR2). In the present study, we examined the mechanism whereby HAT upregulates IL-8 synthesis in HBECs with a focus on PAR2. Northern blot analysis revealed that HAT enhanced IL-8 mRNA expression at concentrations of 10-100 mU/mL. PAR2 activating peptide (PAR2 AP) also enhanced IL-8 release and IL-8 mRNA expression in HBECs at 50-1,000 μM at similar levels as HAT. Knockdown of PAR2 mRNA by siRNA methods showed that PAR2 mRNA expression was significantly depressed in primary HBECs, and both HAT- and PAR2 AP-induced IL-8 mRNA elevation was significantly depressed in PAR2 siRNA-transfected HBECs. Additionally, HAT cleaved the PAR2 activating site (R   [継承]
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誌名 (必須): Archives of Biochemistry and Biophysics ([Elsevier])
(pISSN: 0003-9861, eISSN: 1096-0384)

ISSN (任意): 1096-0384
ISSN: 0003-9861 (pISSN: 0003-9861, eISSN: 1096-0384)
Title: Archives of biochemistry and biophysics
Title(ISO): Arch Biochem Biophys
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 664 [継承]
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(必須): 167 173 [継承]
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年月日 (必須): 西暦 2019年 1月 21日 (平成 31年 1月 21日) [継承]
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DOI (任意): 10.1016/j.abb.2019.01.019    (→Scopusで検索) [継承]
PMID (任意): 30677406    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85061745596 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Mari Miki, Susumu Yasuoka, Rie Tsutsumi, Yoichi Nakamura, Maeda Hajime, Yukiyasu Takeuchi, Keisuke Miki, Seigo Kitada and Ryoji Maekura : Human airway trypsin-like protease enhances interleukin-8 synthesis in bronchial epithelial cells by activating protease-activated receptor 2., Archives of Biochemistry and Biophysics, Vol.664, (号), 167-173, 2019.
欧文冊子 ● Mari Miki, Susumu Yasuoka, Rie Tsutsumi, Yoichi Nakamura, Maeda Hajime, Yukiyasu Takeuchi, Keisuke Miki, Seigo Kitada and Ryoji Maekura : Human airway trypsin-like protease enhances interleukin-8 synthesis in bronchial epithelial cells by activating protease-activated receptor 2., Archives of Biochemistry and Biophysics, Vol.664, (号), 167-173, 2019.

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