『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=359054EID:359054, Map:0, LastModified:2020年9月2日(水) 19:06:06, Operator:[橋本 登], Avail:TRUE, Censor:0, Owner:[橋本 登], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Esaki Nobutoshi (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Ohkawa Yuki (日) (読)
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[継承]
3.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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学籍番号 (推奨):
[継承]
4. (英) Tsuda Yuhsuke (日) (読)
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[継承]
5. (英) Ohmi Yuhsuke (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Bhuiyan H. Robiul (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Kotani Norihiro (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Honke Koichi (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Enomoto Atsushi (日) (読)
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[継承]
10. (英) Takahashi Masahide (日) (読)
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[継承]
11. (英) Furukawa Keiko (日) (読)
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学籍番号 (推奨):
[継承]
12. (英) Furukawa Koichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Ganglioside GD2 is specifically expressed in small-cell lung cancer (SCLC) cells, leading to enhancement of malignant phenotypes, such as cell proliferation and migration. However, how GD2 promotes malignant phenotypes in SCLC cells is not well known. In this study, to reveal the mechanisms by which GD2 increases malignant phenotypes in SCLC cells, we used enzyme-mediated activation of radical sources combined with mass spectrometry in GD2 SCLC cells. Consequently, we identified ASC amino acid transporter 2 (ASCT2), a major glutamine transporter, which coordinately works with GD2. We showed that ASCT2 was highly expressed in glycolipid-enriched microdomain/rafts in GD2 SCLC cells, and colocalized with GD2 in both proximity ligation assay and immunocytostaining, and bound with GD2 in immunoprecipitation/TLC immunostaining. Malignant phenotypes of GD2 SCLC cells were enhanced by glutamine uptake, and were suppressed by L-γ-glutamyl-p-nitroanilide, a specific inhibitor of ASCT2, through reduced phosphorylation of p70 S6K1 and S6. These results suggested that ASCT2 enhances glutamine uptake in glycolipid-enriched microdomain/rafts in GD2 SCLC cells, leading to the enhancement of cell proliferation and migration through increased phosphorylation of the mTOR complex 1 signaling axis.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Transport System ASC (日) (読) [継承]
2. (英) Cell Line, Tumor (日) (読) [継承]
3. (英) Cell Movement (日) (読) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5. (英) Gangliosides (日) (読) [継承]
6. (英) Glutamine (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Lung Neoplasms (日) (読) [継承]
9. (英) Membrane Microdomains (日) (読) [継承]
10. (英) Minor Histocompatibility Antigens (日) (読) [継承]
11. (英) Small Cell Lung Carcinoma (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cancer Science ([日本癌学会])
(pISSN: 1347-9032, eISSN: 1349-7006)

ISSN (任意): 1349-7006
ISSN: 1347-9032 (pISSN: 1347-9032, eISSN: 1349-7006)
Title: Cancer science
Title(ISO): Cancer Sci
Publisher: Wiley-Blackwell
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 109 [継承]
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(必須): 141 153 [継承]
都市 (任意):
年月日 (必須): 西暦 2018年 1月 3日 (平成 30年 1月 3日) [継承]
URL (任意):
DOI (任意): 10.1111/cas.13448    (→Scopusで検索) [継承]
PMID (任意): 29151270    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/cas.13448  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: ASCT2  (日)    [継承]
4.(英) KeywordList.Keyword: GD2  (日)    [継承]
5.(英) KeywordList.Keyword: glutamine transporter  (日)    [継承]
6.(英) KeywordList.Keyword: glycolipid  (日)    [継承]
7.(英) KeywordList.Keyword: small-cell lung cancer  (日)    [継承]

標準的な表示

和文冊子 ● Nobutoshi Esaki, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Tsuda, Yuhsuke Ohmi, Robiul H. Bhuiyan, Norihiro Kotani, Koichi Honke, Atsushi Enomoto, Masahide Takahashi, Keiko Furukawa and Koichi Furukawa : ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer., Cancer Science, Vol.109, No.1, 141-153, 2018.
欧文冊子 ● Nobutoshi Esaki, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Tsuda, Yuhsuke Ohmi, Robiul H. Bhuiyan, Norihiro Kotani, Koichi Honke, Atsushi Enomoto, Masahide Takahashi, Keiko Furukawa and Koichi Furukawa : ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer., Cancer Science, Vol.109, No.1, 141-153, 2018.

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