『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Furukawa Koichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Ohmi Yuhsuke (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Tajima Orie (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Ohkawa Yuki (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Kondo Yuji (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Shuting Ji (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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学籍番号 (推奨):
[継承]
8. (英) Furukawa Keiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Gangliosides in Inflammation and Neurodegeneration.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Gangliosides play roles in the regulation of cell signaling that are mediated via membrane microdomains, lipid rafts. In this review, functions of gangliosides in the maintenance of nervous systems with a focus on regulation of inflammation and neurodegeneration are addressed. During analyses of various ganglioside-lacking mutant mice, we demonstrated that nervous tissues exhibited inflammatory reactions and subsequent neurodegeneration. Among inflammation-related genes, factors of the complement system showed up-regulation with aging. Analyses of architectures and compositions of lipid rafts in nervous tissues from these mutant mice revealed that dysfunctions of complement regulatory proteins based on disrupted lipid rafts were main factors to induce the inflammatory reactions resulting in neurodegeneration. Ganglioside changes in development and senescence, and implication of them in the integrity of cell membranes and cellular phenotypes in physiological and pathological conditions including Alzheimer disease have been summarized. Novel directions to further analyze mechanisms for ganglioside functions in membrane microdomains have been also addressed.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Gangliosides (日) (読) [継承]
3. (英) Humans (日) (読) [継承]
4. (英) Inflammation (日) (読) [継承]
5. (英) Neurodegenerative Diseases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Progress in Molecular Biology and Translational Science ([Elsevier])
(pISSN: 1877-1173, eISSN: 1878-0814)

ISSN (任意): 1878-0814
ISSN: 1877-1173 (pISSN: 1877-1173, eISSN: 1878-0814)
Title: Progress in molecular biology and translational science
Title(ISO): Prog Mol Biol Transl Sci
Publisher: Elsevier B.V.
 (NLM Catalog  (Scopus (Scopus information is found. [need login])
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(必須): 156 [継承]
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(必須): 265 287 [継承]
都市 (任意):
年月日 (必須): 西暦 2018年 4月 10日 (平成 30年 4月 10日) [継承]
URL (任意):
DOI (任意): 10.1016/bs.pmbts.2018.01.009    (→Scopusで検索) [継承]
PMID (任意): 29747817    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: S1877-1173(18)30033-4  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/bs.pmbts.2018.01.009  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) KeywordList.Keyword: aging  (日)    [継承]
6.(英) KeywordList.Keyword: complement  (日)    [継承]
7.(英) KeywordList.Keyword: inflammation  (日)    [継承]
8.(英) KeywordList.Keyword: knockout  (日)    [継承]
9.(英) KeywordList.Keyword: lipid rafts  (日)    [継承]
10.(英) KeywordList.Keyword: neurodegeneration  (日)    [継承]

標準的な表示

和文冊子 ● Koichi Furukawa, Yuhsuke Ohmi, Orie Tajima, Yuki Ohkawa, Yuji Kondo, Ji Shuting, Noboru Hashimoto and Keiko Furukawa : Gangliosides in Inflammation and Neurodegeneration., Progress in Molecular Biology and Translational Science, Vol.156, (号), 265-287, 2018.
欧文冊子 ● Koichi Furukawa, Yuhsuke Ohmi, Orie Tajima, Yuki Ohkawa, Yuji Kondo, Ji Shuting, Noboru Hashimoto and Keiko Furukawa : Gangliosides in Inflammation and Neurodegeneration., Progress in Molecular Biology and Translational Science, Vol.156, (号), 265-287, 2018.

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