『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=357503EID:357503, Map:0, LastModified:2019年8月28日(水) 18:17:34, Operator:[尾矢 剛志], Avail:TRUE, Censor:0, Owner:[尾矢 剛志], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.富山医科薬科大学 [継承]
著者 (必須): 1. (英) Nogami Shigeharu (日) (読)
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[継承]
2. (英) Ishii Yoko (日) (読)
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[継承]
3. (英) Kawaguchi Makoto (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Sakata Nobuo (日) (読)
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[継承]
5.尾矢 剛志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.分子病理学])
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6. (英) Takagawa Kiyoshi (日) (読)
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7. (英) Kanamori Masahiko (日) (読)
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8.小畑 利之
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9. (英) Kimura Tomoatsu (日) (読)
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10. (英) Sasahara Masakiyo (日) (読)
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[継承]
題名 (必須): (英) ZFH-4 protein is expressed in many neurons of developing rat brain.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The zinc finger-homeodomain (ZFH) transcription factors contain a zinc finger motif and a homeodomain that might regulate neural and mesenchymal cell differentiation. We have cloned the ZFH4 gene that encodes a protein with structures closely related to ATBF1. In order to study the expression pattern of ZFH4 in the developing rat brain, we raised an antibody against a glutathione-S-transferase (GST) fusion protein of ZFH4. Western blotting with this antibody identified a gene product of 390 kDa in the normal rat brain. Levels of the protein were high in the brainstem at embryonic and neonatal periods and in the midbrain and diencephalon in neonatal rat brain. In addition, the corresponding mRNA of 12.5 kb was detected by Northern blotting. An immunolocalization study showed that postmitotic neurons in the brainstem were the major site of ZFH4 expression, and the levels of expression varied depending on age and anatomical sites. Expression was transient and weak in precursor cells at early neurogenesis. Although ZFH4 levels decreased after birth, ZFH4 continued to be expressed in the mature neurons including DOPA decarboxylase-positive neurons. High levels of expression were also detected in non-neuronal cells of the subcommissural organ, but the expression was almost undetectable throughout precursor cells to mature neurons in the cerebral cortex and hippocampus. The spatial and temporal expression patterns closely resembled those of ATBF1, and we detected neurons that expressed ZFH4, ATBF1, or both. We postulate that ZFH4 participates in the regulation of neural cell maturation or of region-specific differentiation of the brain.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Northern (日) (読) [継承]
3. (英) Blotting, Western (日) (読) [継承]
4. (brain) [継承]
5.細胞分化 (cell differentiation) [継承]
6. (英) Gene Expression Regulation, Developmental (日) (読) [継承]
7. (英) Homeodomain Proteins (日) (読) [継承]
8.免疫組織化学 (immunohistochemistry) [継承]
9. (英) Nerve Tissue Proteins (日) (読) [継承]
10. (英) Rats (日) (読) [継承]
11. (英) Rats, Wistar (日) (読) [継承]
12. (英) Tissue Distribution (日) (読) [継承]
13. (英) Transcription Factors (日) (読) [継承]
14. (英) Zinc Fingers (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Comparative Neurology (Wistar Institute of Anatomy and Biology)
(pISSN: 0021-9967, eISSN: 1096-9861)

ISSN (任意): 0021-9967
ISSN: 0021-9967 (pISSN: 0021-9967, eISSN: 1096-9861)
Title: The Journal of comparative neurology
Title(ISO): J Comp Neurol
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 482 [継承]
(必須): 1 [継承]
(必須): 33 49 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 1月 初日 (平成 17年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1002/cne.20382    (→Scopusで検索) [継承]
PMID (任意): 15612017    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Pathology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama City 930-0194, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shigeharu Nogami, Yoko Ishii, Makoto Kawaguchi, Nobuo Sakata, Takeshi Oya, Kiyoshi Takagawa, Masahiko Kanamori, Toshiyuki Obata, Tomoatsu Kimura and Masakiyo Sasahara : ZFH-4 protein is expressed in many neurons of developing rat brain., The Journal of Comparative Neurology, Vol.482, No.1, 33-49, 2005.
欧文冊子 ● Shigeharu Nogami, Yoko Ishii, Makoto Kawaguchi, Nobuo Sakata, Takeshi Oya, Kiyoshi Takagawa, Masahiko Kanamori, Toshiyuki Obata, Tomoatsu Kimura and Masakiyo Sasahara : ZFH-4 protein is expressed in many neurons of developing rat brain., The Journal of Comparative Neurology, Vol.482, No.1, 33-49, 2005.

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