| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Takahashi Etsuhisa (日) (読)
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| 2. | (英) Indalao L. Irene (日) (読)
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| 3. | (英) Sawabuchi Takako (日) (読)
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| 4. | (英) Mizuno Keiko (日) (読)
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| 5. | (英) Sakai Satoko (日) (読)
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| 6. | (英) Kimoto Takashi (日) (読)
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| 7. | (英) Kim Hyejin (日) (読)
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| 8. | 木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○題名 (必須): | □ | (英) Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and inproves pathological changes in the lungs and heart of mice infected with influenza A virus. (日)
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| ○要約 (任意): | □ | (英) The influenza A virus (IAV)-cytokine-trypsin/matrix metalloproteinase-9 (MMP-9) cycle is one of the important mechanisms of multiple organ failure in severe influenza. Clarithromycin, a macrolide antibiotic, has immune modulatory and anti-inflammatory effects. We analyzed the effects of clarithromycin on the induction of chemokines, cytokines, MMP-9, trypsin, vascular hyper-permeability and inflammatory aggravation in mice with IAV infection. IAV/Puerto Rico/8/34(H1N1) infection increased the levels of monocyte chemoattractant protein-1 (MCP-1) and cytokines in serum, and MMP-9 and trypsin in serum and/or the lungs and heart. Clarithromycin significantly suppressed the induction of serum MCP-1 and MMP-9 and vascular hyperpermeability in these organs in the early phase of infection, but did not suppress the induction of trypsin, IL-6 or IFN-γ. Histopathological examination showed that clarithromycin tended to reduce inflammatory cell accumulation in the lungs and heart. These results suggest that clarithromycin suppresses infection-related inflammation and reduces vascular hyperpermeability by suppressing the induction of MCP-1 and MMP-9. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Anti-Bacterial Agents (日) (読)
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| 3. | (英) Blotting, Western (日) (読)
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| 4. | (英) Chemokine CCL2 (日) (読)
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| 5. | (英) Clarithromycin (日) (読)
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| 6. | (英) Enzyme-Linked Immunosorbent Assay (日) (読)
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| 7. | 女性 (female)
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| 8. | (英) Influenza A virus (日) (読)
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| 9. | (英) Lung (日) (読)
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| 10. | (英) Matrix Metalloproteinase 9 (日) (読)
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| 11. | (英) Mice (日) (読)
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| 12. | (英) Mice, Inbred BALB C (日) (読)
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| 13. | 心筋 (myocardium)
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| 14. | (英) Orthomyxoviridae Infections (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Comparative Immunology, Microbiology and Infectious Diseases
(pISSN: 0147-9571, eISSN: 1878-1667)
| ○ISSN (任意): | □ | 1878-1667
ISSN: 0147-9571
(pISSN: 0147-9571, eISSN: 1878-1667) Title: Comparative immunology, microbiology and infectious diseasesTitle(ISO): Comp Immunol Microbiol Infect DisPublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 56
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 6 13
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 2月 初日 (平成 30年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.cimid.2017.11.002 (→Scopusで検索)
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| ○PMID (任意): | □ | 29406285 (→Scopusで検索)
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: S0147-9571(17)30095-4 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.cimid.2017.11.002 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: BBB (日)
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| 5. | (英) KeywordList.Keyword: Clarithromycin (日)
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| 6. | (英) KeywordList.Keyword: Evans' blue extravasation (日)
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| 7. | (英) KeywordList.Keyword: IAV (日)
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| 8. | (英) KeywordList.Keyword: Influenza A virus infection (日)
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| 9. | (英) KeywordList.Keyword: MC (日)
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| 10. | (英) KeywordList.Keyword: MOF (日)
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| 11. | (英) KeywordList.Keyword: Macrolide (日)
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| 12. | (英) KeywordList.Keyword: Matrix metalloproteinase-9 (日)
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| 13. | (英) KeywordList.Keyword: Multiple organ failure (日)
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| 14. | (英) KeywordList.Keyword: PID (日)
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| 15. | (英) KeywordList.Keyword: PR8 (日)
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| 16. | (英) KeywordList.Keyword: blood-brain barrier (日)
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| 17. | (英) KeywordList.Keyword: influenza A virus (日)
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| 18. | (英) KeywordList.Keyword: influenza A/Puerto Rico/8/34(H1N1) (日)
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| 19. | (英) KeywordList.Keyword: methyl cellulose (日)
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| 20. | (英) KeywordList.Keyword: multiple organ failure (日)
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| 21. | (英) KeywordList.Keyword: pfu (日)
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| 22. | (英) KeywordList.Keyword: plaque-forming units (日)
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| 23. | (英) KeywordList.Keyword: post-infection day (日)
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