| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Shinozuka Takuma (日) (読)
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| 2. | (英) Takada Ritsuko (日) (読)
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| 3. | (英) Yoshida Chosei (日) (読)
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| 4. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| 5. | (英) Takada Shinji (日) (読)
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| ○題名 (必須): | □ | (英) Wnt produced by stretched roof-plate cells is required for the promotion of cell proliferation around the central canal of the spinal cord (日)
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| ○要約 (任意): | □ | (英) Cell morphology changes dynamically during embryogenesis, and these changes create new interactions with surrounding cells, some of which are presumably mediated by intercellular signaling. However, the effects of morphological changes on intercellular signaling remain to be fully elucidated. In this study, we examined the effect of morphological changes in Wnt-producing cells on intercellular signaling in the spinal cord. After mid-gestation, roof-plate cells stretched along the dorsoventral axis in the mouse spinal cord, resulting in new contact at their tips with the ependymal cells that surround the central canal. Wnt1 and Wnt3a were produced by the stretched roof-plate cells and delivered to the cell process tip. Whereas Wnt signaling was activated in developing ependymal cells, Wnt activation in dorsal ependymal cells, which were close to the stretched roof plate, was significantly suppressed in embryos with roof plate-specific conditional knockout of , which encodes a factor that is essential for Wnt secretion. Furthermore, proliferation of these cells was impaired in conditional knockout mice during development and after induced spinal cord injury in adults. Therefore, morphological changes in Wnt-producing cells appear to generate new Wnt signal targets. (日)
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| ○誌名 (必須): | □ | Development ([The Company of Biologists Limited])
(pISSN: 0950-1991, eISSN: 1477-9129)
| ○ISSN (任意): | □ | 1477-9129
ISSN: 0950-1991
(pISSN: 0950-1991, eISSN: 1477-9129) Title: Development (Cambridge, England)Title(ISO): DevelopmentPublisher: Company of Biologists (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 146
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | dev159343 dev159343
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| ○年月日 (必須): | □ | 西暦 2019年 1月 16日 (平成 31年 1月 16日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1242/dev.159343 (→Scopusで検索)
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| ○PMID (任意): | □ | 30651295 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: dev159343 (日)
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| 2. | (英) Article.ELocationID: 10.1242/dev.159343 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Morphogen (日)
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| 5. | (英) KeywordList.Keyword: Mouse (日)
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| 6. | (英) KeywordList.Keyword: Neural stem cell (日)
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| 7. | (英) KeywordList.Keyword: Regeneration (日)
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| 8. | (英) KeywordList.Keyword: Roof plate (日)
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| 9. | (英) KeywordList.Keyword: Spinal cord (日)
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| 10. | (英) KeywordList.Keyword: Wnt (日)
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| 11. | (英) CoiStatement: Competing interestsThe authors declare no competing or financial interests. (日)
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