| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 徳島大学以外での国際共著 (徳島大学以外での複数の国の研究機関による共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Honda Akira (日) (読)
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| 2. | (英) Kita Tomoko (日) (読)
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| 3. | (英) Seshadri Vidhya Shri (日) (読)
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| 4. | (英) Misaki Kazuyo (日) (読)
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| 5. | (英) Ahmed Jamal (日) (読)
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| 6. | (英) Ladbury E. John (日) (読)
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| 7. | (英) Richardson P. Guy (日) (読)
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| 8. | 米村 重信
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| 9. | (英) Lather K. Raj (日) (読)
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| ○題名 (必須): | □ | (英) FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The mechanosensory hair cells of the inner ear are required for hearing and balance and have a distinctive apical structure, the hair bundle, that converts mechanical stimuli into electrical signals. This structure comprises a single cilium, the kinocilium, lying adjacent to an ensemble of actin-based projections known as stereocilia. Hair bundle polarity depends on kinociliary protocadherin-15 (Pcdh15) localization. Protocadherin-15 is found only in hair-cell kinocilia, and is not localized to the primary cilia of adjacent supporting cells. Thus, Pcdh15 must be specifically targeted and trafficked into the hair-cell kinocilium. Here we show that kinocilial Pcdh15 trafficking relies on cell type-specific coupling to the generic intraflagellar transport (IFT) transport mechanism. We uncover a role for fibroblast growth factor receptor 1 (FGFR1) in loading Pcdh15 onto kinociliary transport particles in hair cells. We find that on activation, FGFR1 binds and phosphorylates Pcdh15. Moreover, we find a previously uncharacterized role for clathrin in coupling this kinocilia-specific cargo with the anterograde IFT-B complex through the adaptor, DAB2. Our results identify a modified ciliary transport pathway used for Pcdh15 transport into the cilium of the inner ear hair cell and coordinated by FGFR1 activity. (日)
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| ○キーワード (推奨): | 1. | (英) Adaptor Proteins, Vesicular Transport (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Cadherins (日) (読)
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| 4. | (英) Chick Embryo (日) (読)
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| 5. | (英) Clathrin (日) (読)
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| 6. | (英) Flagella (日) (読)
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| 7. | (英) Hair Cells, Auditory, Inner (日) (読)
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| 8. | (英) Mice (日) (読)
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| 9. | (英) Phosphorylation (日) (読)
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| 10. | (英) Protein Precursors (日) (読)
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| 11. | (英) Protein Transport (日) (読)
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| 12. | (英) Receptor, Fibroblast Growth Factor, Type 1 (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Proceedings of the National Academy of Sciences of the United States of America ([The National Academy of Sciences of the United States of America])
(pISSN: 0027-8424, eISSN: 1091-6490)
| ○ISSN (任意): | □ | 1091-6490
ISSN: 0027-8424
(pISSN: 0027-8424, eISSN: 1091-6490) Title: Proceedings of the National Academy of Sciences of the United States of AmericaTitle(ISO): Proc Natl Acad Sci U S APublisher: National Academy of Sciences (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 115
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| ○号 (必須): | □ | 33
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| ○頁 (必須): | □ | 8388 8393
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 8月 18日 (平成 30年 8月 18日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1073/pnas.1719861115 (→Scopusで検索)
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| ○PMID (任意): | □ | 30061390 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1073/pnas.1719861115 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) KeywordList.Keyword: ciliogenesis (日)
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| 5. | (英) KeywordList.Keyword: fibroblast growth factor (日)
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| 6. | (英) KeywordList.Keyword: inner ear (日)
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| 7. | (英) KeywordList.Keyword: protein trafficking (日)
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| 8. | (英) KeywordList.Keyword: signaling (日)
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| 9. | (英) CoiStatement: The authors declare no conflict of interest. (日)
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