| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Goto So (日) (読)
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| 2. | (英) Onishi Akishi (日) (読)
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| 3. | (英) Misaki Kazuyo (日) (読)
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| 4. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| 5. | (英) Sugita Sunao (日) (読)
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| 6. | (英) Ito Hiromi (日) (読)
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| 7. | (英) Ohigashi Yoko (日) (読)
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| 8. | (英) Ema Masatsugu (日) (読)
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| 9. | (英) Sakaguchi Hirokazu (日) (読)
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| 10. | (英) Nishida Kohl (日) (読)
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| 11. | (英) Takahashi Masayo (日) (読)
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| ○題名 (必須): | □ | (英) Neural retina-specific Aldh1a1 controls dorsal choroidal vascular development via Sox9 expression in retinal pigment epithelial cells (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) VEGF secreted from retinal pigment epithelial (RPE) cells is responsible for the choroidal vascular development; however, the molecular regulatory mechanism is unclear. We found that mice showed choroidal hypoplasia with insufficient vascularization in the dorsal region, although Aldh1a1, an enzyme that synthesizes retinoic acids (RAs), is expressed in the dorsal neural retina, not in the RPE/choroid complex. The level of VEGF in the RPE/choroid was significantly decreased in mice, and RA-dependent enhancement of VEGF was observed in primary RPE cells. An RA-deficient diet resulted in dorsal choroidal hypoplasia, and simple RA treatment of pregnant females suppressed choroid hypoplasia in their offspring. We also found downregulation of Sox9 in the dorsal neural retina and RPE of mice and RPE-specific disruption of Sox9 phenocopied choroidal development. These results suggest that RAs produced by Aldh1a1 in the neural retina directs dorsal choroidal vascular development via Sox9 upregulation in the dorsal RPE cells to enhance RPE-derived VEGF secretion. (日)
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| ○キーワード (推奨): | 1. | (英) Aldehyde Dehydrogenase (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Choroid (日) (読)
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| 4. | (英) Epithelial Cells (日) (読)
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| 5. | (英) Gene Expression Regulation (日) (読)
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| 6. | (英) Mice, Inbred C57BL (日) (読)
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| 7. | (英) Mice, Knockout (日) (読)
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| 8. | (英) Neovascularization, Physiologic (日) (読)
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| 9. | (英) Retinal Pigment Epithelium (日) (読)
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| 10. | (英) SOX9 Transcription Factor (日) (読)
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| 11. | (英) Tretinoin (日) (読)
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| 12. | (英) Vascular Endothelial Growth Factor A (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | eLife (eLife Sciences Publications, Ltd.)
(eISSN: 2050-084X)
| ○ISSN (任意): | □ | 2050-084X
ISSN: 2050-084X
(eISSN: 2050-084X) Title: eLifeTitle(ISO): ElifePublisher: eLife Sciences Publications (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ |
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 4月 3日 (平成 30年 4月 3日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.7554/eLife.32358 (→Scopusで検索)
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| ○PMID (任意): | □ | 29609731 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85051983205
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.7554/eLife.32358 (日)
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| 2. | (英) Article.ELocationID: e32358 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) KeywordList.Keyword: Aldh1a1 (日)
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| 6. | (英) KeywordList.Keyword: Sox9 (日)
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| 7. | (英) KeywordList.Keyword: VEGF (日)
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| 8. | (英) KeywordList.Keyword: choroid (日)
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| 9. | (英) KeywordList.Keyword: developmental biology (日)
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| 10. | (英) KeywordList.Keyword: mouse (日)
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| 11. | (英) KeywordList.Keyword: neuroscience (日)
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| 12. | (英) KeywordList.Keyword: retinal pigment epithelium (日)
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| 13. | (英) KeywordList.Keyword: retinoic acid (日)
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| 14. | (英) KeywordList.Keyword: stem cells (日)
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| 15. | (英) CoiStatement: SG, AO, KM, SY, SS, HI, YO, ME, HS, KN, MT No competing interests declared (日)
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